Path - Joints Flashcards
Components of synovial joints
Joint space - lines joint cavity & articulating bones w layer of cartilage
Articular cartilage - hyaline cartilage, 70-80% water
Synoviocytes - produce fluid for synovial fluid
Chondrocytes - cells within cartilage; collagen - structural proteins & glycans - non structural proteins
Morphologic features of articular cartilage
Hyaline cartilage
Chondrocytes : collagen & glycans
TM : tide marker, junction between articulate & calcified cartilage
Morphologic features of subchondral bone
Morphologic features of synovium
Traumatic joint injury
Example of traumatic joint injury
Arthrogryposis
Congenital joint contracture, infant animal is born with limbs and joints splayed in various directions due to lack of movement & joint configuration in the womb
Pathogenesis of arthrogryposis
Sporadic - random/unknown
Intrauterine viral infection
- akabane virus
- blue tongue virus (Culicoides)
- schmallenberg virus
Hereditary CNS disease
Toxins - lupine plants & poison hemlock
Pathogenesis of degenerative joint disease
Chronic, destructive disease of synovial joints
Common sequel to various forms of joint injury
Inciting causes of degenerative joint disease
Age
Conformational defects : hip dysplasia, patellar luxation, osteochrondrosis
Excessive wear/use : athletic animals
Joint inflammation : synovitis, arthritis
Complex path of DJD
Damage to Chondrocytes
Proteoglycan depletion = dehydration
Loss of normal articular cartilage viscosity
Progressive loss of cartilage due to normal biomechanial forces (movement)
Release of cytokine/GF = inflammation, 2nd response
Cartilage matrix degradation > repair
Eburnation
“Like ivory”
Degeneration/wear in subcondylar bone, whitening appearance & polishing
Fibrillation of cartilage
Fissure is damage or a tear in cartilage, fibrillation is the sub acute or chronic condition with multiple fissures present in cartilage
What DJD is common in horses?
Navicular syndrome
Degenerative arthropathy of navicular bone
Common in fore limbs or abnormal foot conformation
What animal is osteophytes commonly found w DJD?