Enzymes And Muscles Flashcards
Large animal enzyme chemistry
GGT
AST
CK
SDH
Small animal chemistry
ALT
ALP
Leakage enzymes
AST, CK, ALT, SDH, LDH, AMS, LPS
Induction enzymes
GGT ALP
Causes for enzyme increase
Hemolysis & lipemia
- renal disease : AMS & LPS
Hyperplasia
- L-GGT & B-ALP
Ingestion - colostrum GGT
Features of creatine kinase
Short half life, correlates w severity of damage
Causes for elevated CK
Rhabdomyolysis
- capture myopathy
- Exertional myopathy
Recumbence - LA
Hemolysis
Young age
Seizures/strenuous activity
Selenium deficiency
Causes for AST increase
Muscle, hepatic, cardiac injury
Longer half life
Resolution - v CK ^ AST
Ongoing disease - ^ CK ^ AST
Features of ALT
Long half life
Liver specific is SA
Hemolysis + muscle injury can elevate
Anticonvulsants + steroids great increase
Hyperthyroidism in cats ^^^
Myoglobin vs hemoglobin
Hemo - red plasma = hemoglobinuria
Myo - normal plasma = myoglobinemia
Other chemistry markers for muscle injury
Hyperkalemia
Hypoatremia
Hypochorlidemia
Hyperphosphatemia
Hypocalcemia