Path: Bone: 2 Flashcards

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1
Q

Bone and Soft tissue tumors more often benign or malignant

A

benign by far

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2
Q

For bone and soft tissue sarcomas,what is extremely important for px

A

HISTOLOGIC GRADE

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3
Q

Kids vs. adults: who has more malignant tumors

A

adults

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4
Q

5 tumors that frequently mets to bone (and mnemonic)

A

Prostate, breast, thyroid, lung, kidney (PT Barnum Loves Kids)

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5
Q

ALL sarcomas of bone and soft tissue metastasize to what organ more than any other organ

A

lungs

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6
Q

Are blastomas malignant or benign

A

benign

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7
Q

What does grade mean?

A

Grade: degree of differentiation

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8
Q

What location i smore often beingn: peripheral or central

A

peripheral

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9
Q

What 4 sarcomas display Lymphatic spread:

A

i. Synovial sarcoma
ii. Epithelioid sarcoma
iii. Rhabdomyosarcoma
Pedriatric sarcomas

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10
Q

Treatment of soft tissue tumors

Benign:

A

observe, surgical excision

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11
Q

Which 2 sarcomas respond to chemo only?

A

Rhabdomyosarcoma

Synovial sarcoma

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12
Q

What 4 pre-existing conditions cause soft-tissue tumore

A

i. Paget disease
ii. Infarcts
Radiation injury
Immunosuppresion

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13
Q

Kaposi sarcoma is caused by what

A

HHV-8

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14
Q

EBV causes what kind of tumors

A

EBV- smooth muscle tumors

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15
Q

marker: Ewing’s sarcoma:

A

t(11;22),

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16
Q

marker: Synovial sarcoma:

A

t(X;18)

17
Q

marker Myxoid chondrosarcoma

A

t(9;22)

18
Q

marker: Myxoid/round cell liposarcoma:

A

FUS/DDIT3

19
Q

mortality for bone tumors

A

50% die

20
Q

which presents with pain: bone or soft tissue tumor

A

bone

21
Q

MC malignant bone tumors in adults (2)

A

(metastatic carcinoma, myeloma)

22
Q

****rank MC malignant bone tumors (3)

A

Osteosarcoma > chondrosarcoma > Ewing’s sarcoma

23
Q

rank 2 MC malignant bone tumors in 10-20s

A

Ewing’s sarcoma > osteosarcoma

24
Q

Which bone tumor is bimodal dist

A

osteosarcoma

25
Q

rank MC malignant bone tumors in 50-70s (4)

A

50s-70s: plasmacytoma > metastases > chondrosarcoma > Osteosarcoma

26
Q

rank MC benign bone tumors (2)

A

non-ossifying fibroma > endochondroma

27
Q

What is best method for dx the “agressiveness” of a tumor.

A

Radiology

28
Q

tx of Ewing’s sarcoma:

A

chemo

29
Q

tx of osteosarcoma (3)

A

pre-operative chemo
Surgical resection
Post-operative chemo

30
Q

tx of Chondrosarcoma:

A

Surgical resection