Oxytocics and Tocolytics (online) Flashcards
Oxytocics MOA
stimulate uterine contraction
Tocolytics: MOA
relax uterus
name 5 categories of oxytocics
Estrogen prostaglandins Ergot alkaloids Mefipristone oxytocin
name 5 types of tocolytics
MgSO4 B-blockers indomethacin nifedipine progesterone
What happens to oxytocin effects at uterus during preganancy
receptors increase during pregnancy so uterus becomes more sensitive to oxytocin
oxytocin is similar to what homo
ADH
oxytocin is made where specifically
paraventricular nucleus of hypothalamus
What type of reflex is oxytocin release?
neuroendocrine reflex
What are two broad types of stimulation of oxytocin release and examples
mechanical stimulation: breast, uterus, vagina
auditory: suckling, crying child
Pitocin: administration, relative half-life, and therapeutic uses
(IM, IV)
Short half-life controls uterine activity (overstimulation can kill fetus)
uses: Post-partum can stimulate sustained contraction that limits blood loss
Used to maintain labor in twin deliveryor to expel placenta
Prostaglandin E2: administration, relative half-life, and therapeutic uses
vaginal suppository
uses:
1. Contract both gravid and non-gravid uterus
2. ripens the cervix so you don’t contract uterus against closed cervix
3. Abortifacient (see #1)
4. Post-partum bleeding
Ergot alkaloids: administration, relative half-life, and therapeutic uses
IV or IM
Both have long half-lives so they are only used for postpartum bleeding control.
Not used for labor induction.
2 names of ergot alkaloids
Ergonovine, Methylergonovine
which oxtocics are used for post partum bleeding
Oxytocin, PGs, Ergots (all 3!)
Which oxytoxcics are used for abortion
PGs, with or without RU-486
