Hemorrhagic fever viruses Flashcards
what are the 3 bunyaviruses
Crimean Congo Hemorrhagic Fever
Rift Valley Fever Virus
Hantavirus
2 Arean viruses?
Lymphocytic Choriomeningitis Virus-LCMV
Lassa Fever
How are Crimean Congo Hemorrhagic Fever
Rift Valley Fever Virus (2)
Hantavirus transmitted
Crimean Congo Hemorrhagic Fever = tick bite
Rift Valley Fever Virus = mosquito/handling livestock
Hanta = rodent feces/urine
What is CFR of Crimean Congo Hemorrhagic Fever
Rift Valley Fever Virus
Hantavirus
Crimean Congo Hemorrhagic Fever = 30%
Rift Valley Fever Virus = 1%
Hantavirus = 36%
what 2 diseases does Hanta virus cause and which is Europe/asia and which is Americas?
North and South America: Hantavirus Pulmonary Syndrome.
Europe/Asia: Hemorrhagic Fever with Renal Syndrome (HFRS)
which is more deadly (and CFR): Hantavirus Pulmonary Syndrome (HPS) or Hemorrhagic Fever with Renal Syndrome (HFRS)?
Hantavirus Pulmonary Syndrome (HPS) = 36% CFR (america)
Hemorrhagic Fever with Renal Syndrome (HFRS) = 1% CFR
How is Lymphocytic Choriomeningitis Virus-LCMV transmited?
Urine, feces, saliva, blood or bite of wild mouse or pet mouse, hamster, or guinea pig
main reservoir of Lymphocytic Choriomeningitis Virus-LCMV
house mice
2 main diseases associated with LCMV and what 2populations of people have the most serious outcomes with infection
□ meningitis, encephalitis
Very fatal in transplant recipients
infx in 1st trimester = miscarriage, later = birth defects
main disease with Lassa virus and about how many actually develop the serious complications
Lassa fever
20% get serious conditions
what 2 pops have the most serious complications with Lassa infections?
□ Pregnant women = 80% mortality if infected in third trimester
® Fetal loss is 80-90% in all stages of pregnancy.
Lassa is fatal for neonates.
What antiviral is used to treat all arenaviruses?
Ribavarin
when in Lassa infections is Ribavarin most effective?
Best if given within 6 days of infection
What is the reservoir and the most probable means of spread of Ebola/Marburg virus to humans?
□ Reservoir = bat
Other animals like non-human primates can become infected and spread the disease to humans.
when does Ebola pt becom ein fectious
once a fever develops: 2 to 21 days after exposure.