Path 20: Kidney no make pee Flashcards
Post strep glomerulonephiritis timeline and IF/EM
1-4 weeks
Granular staining pattern for IgG and C3 humps of immune complexes
Renal tubular acidosis types
1: Distal renal
2: Proximal renal
4: Hyperkalemic
Distal renal tubular acidosis pathogenesis
Inability of α-intercalated cells to secrete H+
Distal renal tubular acidosis findings
Decreased serum K+.
Urine pH above 5.5
Renal tubular acidosi: what type of acidosis ?
Normal anion gap
Proximal renal tubular acidosis pathogenesis
PCT HCO3 reabsorption is impaired leading to increased urine HCO3
Hyperkalemic tubular acidosis pathogenesis
Hypoaldosterone or aldosterone resistance leads to hyperK. Leads to decreased NH4 excretion
Labs in type 4 tubular acidosis
Increased serum K+
Fanconi sx sumptoms
Generalized PCT reabsoroption defect. Leads to excretion of all PCT absorbed sunstances
Barter syndrome pathogenesis and findings
Na/+K+/2Cl- defect
Acts like lasix
Metabolic alkalosis, hypoK, hypercalciuria
Liddle syndrome caused by
Gain of function leads to decrease in Na+ degredation and increase in Na+ reabsorption in collecting tubule
RBC casts seen with
Glomerolonephritis, HTN
WBC casts seen in
Tubulointerstitial inflamation, pyelonephritis
Granular casts seen in ? and appearance
Acute tubular necrosis
“Muddy brown”
Fatty casts seen in and visual
Nephrotic syndrome
Maltese cross
Waxy casts seen in
ESRF
Neprhitic syndrome presentation
Hematuria, RBC casts, oligouria, HTN
Nephritic syndrome etiology
Glomerula inflammation leads to GBM damage
Leads to RBC loss and hematuria
Nephrotic syndrome etiology
Podocyte damage fucks with charge barrier leading to proteinuria
Nephrotic syndrome findings
Massive proteinuria with edema, frothy urine, hypercoagulable state
PSGN post strep pathology
2-4 weeks after strep infection. Type III hypersensitivity
PSGN light IF
Starry sky/ granular appearance.
IgG, IgM and C3 deposition in GBM and mesangium
PSGN Electron microscopy
Subepithelilial IC humps
RPGN features
Rapid deterioration, cresents
RPGN and linear IF:
Goodpasture syndrome (Type II hypersensitivity)
RPGN and negative IF:
Granulomatosis
C-ANCA, MPO-ANCA, p-ANCA
RPGN and Granular IF
diffuse proliferative glomerulonephritis