Path 17-18 GI and Liver Flashcards
Duodenal atresia cause
Failure to recanalize
Duodenal atresia sx
Bilious vomit and abd distension
Pyloric stenosis presentation
Palapable mass, nonbilious vomit at 2-6 weeks
Eosiniphilic esophagitis cause
Food allergens
Plummer vinson syndrome
DIES
Dysphagia, iron deficiency, esophageal webs, squamous cell carcinoma
Barret esophagus caused by
GERG
Barret esophagus pathology
Intestinal metaplasia replaces squamous epithelium
Esophageal cancer: portions affected
Squamous: Top 2/3
Adenocarcinoma: Bottom 1/3
NSAID gastritis how
decreased PGE2 means leads to lower gastric mucosa protection
Cushing ulcer pathogenesis
Vagal stim —> ACh increases —> H+ increases
Autoimmune gastritis caused by
Autoantibodies to H+/K+ ATPase on parietal cells
H pylori vs autoimmune gastritis location
H pylori antrum
Autoimmune body and fundus
Menetier disease pathology
Hyperplasia of gastric mucosa make rugae
Decreased acid production
Edema and other GI sx
Gastric adenocarcinoma outward signs
Virchow node, sister mary joseph node
Acanthosis nigricans
Celiac disease findings
IgA antitissue transglutaminase
Crypt hyperplasia
Gliadin peptide antibodies
Villious atrophy
Tropical sprue caused by
Infection. Infectious celiac. Pathogen unk
Whipple disease cause
Tropheryma whilpplei cause
Whipple disease histo and sx
PAS+ foamy macrophages
Cardiac, Arthralgia, Neuro sx
PAS FOAMY WHIPPED CAN
Chrons location
Ususally colon, spares rectum
Skip lesions
Ulcerative colitis location
Whole colon, continous
Chrons morphology
Fistulas, cobblestone mucosa, string sign on barium swallow, linear fissures
Chron disease histo
Non caseating granulomas and lymphoid aggregates
Ulcerative colitis location
Only affects mucosa and submucosa
LEAD PIPE appearance (no haustra)
Ulcerative colitis histo
Crypt absecess and bleeding
Chrons vs UC disease mediated by
Chrons Th1
UC Th2
UC vs Chrons: bloody diahreah?
UC: bloody
Chrons: sometimes bloody
Ulcerative colitis associated antibodies
p-ANCA
Toxic megacolon seen with (chrons/UC)
Ulcerative colitis
McBurney point location
1/3 distance from ASIS to ubilicus
Diverticulosis pathology
MAny false diverticula in colon
Diverticulitis presentation
LLQ pain, fever, leukocytosis
Meckel vs false diverticulum
Meckel: all layers
False: only mucosa and submucosa
Zenker diverticulum pathology
False diverticulum at Killian triangle
Hirshprung dx pathogenesis
Congenital lack of nervous plexus in distal colon leads to toxic megacolon
Hirschprung disease embryo cause
Failure of neural crest cell migration
Hirschprung disease gene abnormality
RET
Volvulus xray appreance
Coffee been sign
Intussuseption sx
PAin, bloody red jelly stool
Most common small bowel obstruction
Adhesion s/p surgery
Hamartoma polyps associated with
Peutz-Jeghers syndrome
Adenomatous polyp histo
Tubular or Villous
Villous more cancerous
Adenomatous polyps gene
APC KRAS
Familial denomaptous polyposis gene
Autosomal domminant APC tumor suppression gene
Gardner syndrome
FAP (familial polyposis) + soft tissue or bone tumor
Turcot syndrome
FAP (famililal polyposis) + neural tumors
Colon cancer presentation
Iron deficiency anemia in elderly, IBD, apple core xray, weight loss
Colorectal cancer tumor marker
CEA
Smoking protective for
Ulcerative colitis
Colon cancer gene mutation
APC —> KRAS —>TP53
AK 53
Cirrhosis cell type
Stellate cells
Cirrhosis histo
Difuse fibrosing by stellate cells, regenerative nodules
Primary bacterial peritonitis sx
ASCITES Sepsis, ileus, diagnosed by high neutrophils in ascitic fluid
In alcoholic live which transferase is elevated more
AST > ALT
Alk phos goes up in _____
Bone disease and cholestasis
Reye syndrome MOA
Aspirin metabolites decrease β oxidation by inhibiting mitochondria. Fucks up liver
Reye syndrome sx
SHINE
Steatosis of liver
Hypoglycemia
Infection
Not alert
Encephalopathy
Hepatic steatosis
Macrovesicular fatty change
reversible
Alcoholic hepatitis histo
Swollen and necrotic hepatocytes with neutrophil inflammation
Mallory bodies
Nonalcaholic fatty liver dx moa
Insulin resistance leads fatty infiltration of hepatocytes
Most common primary malignancy of liver
Hepatocellular carcinoma
Virus that causes hepatocellular cancer
HBV
Hepatocellular carcinoma clinical features
Jaundice, ascites, hepatomegaly polycethemia
Hepatocellular carcinoma labs
elevated α-fetoprotein
Angiosarcoma of liver is from what exposure
Arsenic, vinyl chlorida
Most common benign liver tumor
Cavernous hemangioma
Budd chiari syndrome pathology
Thrombosis/compression of hepatic vein causes congestive liver sx.
Causes of jaundice
HOT Liver
Hemolysis
Obstruction
Tumor
Liver dx
α1- anti trypsin pathogenesis liver
Misfolder gene product with protein aggregates in hepatocellular ER
α1- antitrypsin liver progression
Causes PAS+ cirrhosis
Conjugated hyperbillirubinemia causes
Biliary obstruction
Dubin Johnson
Rotor syndrom
Unconjugated hyperbilirubiemia caused by
Hemolytic anemia , gilbert syndrome, Crigler-najjar
Pysiologic neonatal jaundice caused by
immature UDP-glucuronosyltransferase
Billiary atresia presentation
Jaundice 2 weeks after birth, dark urine, acholic stool
Elevated direct bilirubin and GGT
Biliary atresia pathogenesis
Fibro-obliterative destruction of extra hepatic bile ducts
Heriditary hyperbilirubenimias genetics
autosomal recessive
Gilber syndrome pathogenesis
decreased UPD-glucoronosyltransferase activity
Gilbert syndrome presentations
Assymptomatic jaundice after stress
Crigler Najjar syndrome pathogenesis
UPD-glucoronosyltransferase leads to no conjugation
Crigler-Najjar findings
Jaundice, kernicters, increased indirect bilirubin
Dubin johnson pathogenesis and findings
Conjugated hyperbili from defective liver excretion
Black liver
Wilson disease gene mutation and chromosome
13
ATP7B gene
Wilson disease pathogenesis
Copper transport ATPase means copper cant be excreted into bile. Copper accumulates and is found in urine
Wilson disease findings
Low ceruloplasmin
Eye rings, neuropsych issues, renal dx (fanconi)
Wilson dx treatment
Copper chelation with penicillamine and oral zinc
Hemochromatosis genetics
autosomal recessive
HFE gene
chromosome 6
Hemochromatosis pathogenesis
Abnormal iron sensing leads to increased intestinal absorption
Iron overload
Hemochromatosis labs
Elevated: ferritin, iron, transferin
Decreased: TIBC
Hemocrhomatosis presentation
Cirrhosis, diabetes, bronze skin
Hemochromatosis cardiac complication
Restrictive cardiomyopathy
Biliary tract disease presentation
Pruritus, jaundice, dark urine, light colored stool
Cholestatic pattern (lab values)
Increased: Conjugated bilirubin, cholesterol, AlkPhos, GGT
Primary sclerosing cholangitis pathology
Onion skin bile duct fibrosis
Primary sclerosin cholangitis patient population
Middle aged men w/ UC
Primary sclerosing colangitis associated conditions and labs
Ulcerative colitis (p-anca)
Increased IgM
Can lead to cholangiocarcinoma and gall cancer
Primary biliary cholangitis pathology
Autoimumine reaction
Lymphocytic infiltrate with destruction of lobular bile ducts
Primary biliary cholangitis seen (population)
Middle age woman
Primary biliary cholangitis additional findings
Anti-mitochondichondrial antibodies
Increased IGM
Associated with autoimmune conditions
Risk factors for gall stones
4 Fs
Fat female fertile forty
Cholesterol stones feautues
Yellow
Radiolucent
Cholesterol stones seen in
Chrons dx, elderly
Bilirubin stone features
Black
Radiopaque
Infectious stone features
Brown, radiopaque
Gall stone causes
Increased cholesterol or bilirubin
Decreased bile salts
Gallbladder stasis
Biliary colic caused by
Neurohormonal activation
Cholecystitis causes
Calculous: stones
Acaclulous: gallbladder stasis, shock
Gallstone ileus
Gallbladder/GI tract fistula leads to stone entering lumen and obstructing ileocecal valve
Porcelain gall bladdercaused by
Chronic cholecystitis
Porcelain gallbladder increases risk of
Gallbladder adenocarcinoma
Ascending cholangitis findings
Really fucking sick
Fever, RUQ, jaundice
plus shock and AMS