Path Flashcards

1
Q

Lomitapide

A

microsomal tg transfer protein
VLDL decrease in liver

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2
Q

Increased reticulocyte

A

increased erthyropoiesis

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3
Q

Tumour lysis syndrome

A

Rasied K / Phos / Urate
Decreased Calcium

Leukaemia and lymphoma

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4
Q

Porphyria

A

Hb / peroxidase / P450

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5
Q

Rivaroxaban antidote

A

Andexanet Alfa

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6
Q

Essential Thrombocytosis increased

A

increased platelets
increased stroke

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7
Q

DIC

A

Increased
- INR
- APTT
- D-Dimer
Decreased
- Platelets

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8
Q

PT time

A

ext and common pathway

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9
Q

Second most common childhood inheirted condition

A

Schwachman Diamond Syndrome - pancreas

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10
Q

CLL

A

Ibrutinib - typrosine kinase Inhibitor

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11
Q

Bullous Pemphigoid

A

anti-hemidesmosome

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12
Q

Crohns

A

infliximab - TNF alpha
Not use with TB

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13
Q

Mantoux

A

Tuberculin purifed protien derivative

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14
Q

CGD

A

Interferon gamma

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15
Q

Azathiroprine

A

6-Mercaptopurine

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16
Q

Hyperosmolar Hyperglycaemic state

A

diabetes
toilet
increase glucose and osmolality not postassium
HONK

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17
Q

Evolocumab

A

decreased LDL
PCKS9

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18
Q

Fam HyperC

A

increased LDL

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19
Q

Osteomalacia

A

decreased vit D / Ca / phosphate
increased PTH / ALP
mobility

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20
Q

PseudoHypoTH

A

resistance
4th and 5th metac
normal Ca

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21
Q

Type 3 hyperlipoproteinemia

A

increased C and TG
APOE2
alzheimers

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22
Q

Rapid progressive glomerulonephritis

A

SLE / blood / protein
urea and creatinine up
nephritic

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23
Q

Acute alcoholic Hep

A

less than 24 hours
AST > ALT > ALP

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24
Q

HH

A

AR

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25
ALT
Viral Hepatitis
26
Most common breast cancer
Invasive ductal carcinoma
27
Acute infectious glomerulonephritis
blood / froth history of fever htn
28
Aspirgillous
Methenamine silver stain PCP - silver stain
29
Mucocutaneous Leishmaniasisi
travel, sores, mouth, sand fly and macrophages visceral = liver - splenic aspiration cut = skin
30
Listeriosis
gastroenteritis +ve rod ampicillin
31
Reticulocyte
polychromatic and stain RNA
32
Imatinib
CML
33
SCD
defect in beta chain - HBSS
34
Heparin induced thrombocytopaenia
prothrombotic immune complex pt factor 4
35
CML
Increased - WCC - Neutrophil LUQ Pain
36
Mild ITP
No treatment Pt over 50
37
DVT investigation order
D dimer CXR USS Doppler
38
Dyskertosis congenita
Pancytopaenia
39
CLL
CD19 CD5 Increased - Lymphocyte Painless cervical lymphadenopathy
40
Common variable ID
Low - IgG - IgM Give - IvIG
41
Bruton Agammglobinaemia
recurrent infections low lymphocyte, b cell and normal T cell low IgM, G and A
42
ATP
Targets - GP IIb/IIIa
43
Anti-Ro at birth with SLE
Congential heart block
44
X linked SCID
IL-2 shows after 28 days eczema / diarrhoea fever no T / no B, normal neutrophil
45
TNF Alpha
RA / Amyloidosis / IBD
46
Ezetimibe
NPC 1L1 Decrease - Cholesterol Absorption
47
Allopurinol
Xanthine oxidase inhibitor
48
Lead
Sideroblastic anaemia Hyperuricaemia Low HB associated with Alcohol
49
Tangier
orange tonsil peripheral neuropathy low HDL ABCA1
50
Bile acids formation
Cholesterol 7 alpha hydroxylase
51
Osteoscleorsis
Increased bone density
52
Best measure for urinary protein loss
24 hour urine collection
53
Lesch Nyhan
Hyperuricaemia HGPRT X-linked
54
Fanconi Syndrome
PCT not work - urine/glucose and protein Rickets HypoK ph - alkaline no ketones failure to thrive
55
G6PD
Jaundice unconjugated VR DAT Negative
56
Hereditary spherocytosis
Eosin 5 maleimide
57
Shortest half life plt
Factor 7 inhibited fastest
58
Shwachman Diamond Diamond blackfan
neutoropenia anaemia
59
ACD
low - TIBC high ferritin pathology
60
Dyskeratosis congenita
Primary bone marrow nail dystropy pigmentation aplastic / pulmonary fibrosis telomeres
61
4T score
probability of getting heparin induced thrombocytopenia platelet factor 4
62
Anti-GBM
type IV collagen
63
JC virus
Progressive multifococal leukoencephalopathy
64
MS monoclonal
Natalizumab
65
SCID
Reticular dysgeneis
66
Inactivated vaccine examples
rabies and HepA
67
Degranulation
Neutrophil release enzymes
68
GC 2
antibodies against own tissue
69
Calineurin
Cyclosporine - gingiuvial hyperplasia Tacrolimus
70
Coaliac and graves
DQ2 DQ3
71
FNHTR
IL1 fever packed RBCs
72
Hyperkalaemia
sine wave broad complex tachy
73
Orlistat
Lipases
74
Blood sulfonylureas
factitious hypog too much insulin (exogenous)
75
Azathioprine
Xanthine oxidase inhibitor with it otherwise tmpt (Thiopurine methyltransferase)
76
RLS step in de novo purine synthesis
PAT
77
Wilsons
Renal tubular acidosis hypokalaemia
78
MEN1
Pituitary adenoma
79
Fracture
ALP
80
Pancreatic cancer
CT abdomen adenocarcinoma
81
HTN and T2DM
TIA
82
T1DM
MRI optic and brain nerves with retroocular pain
83
Copper stain
Rhodanine
84
Ductal carcinoma in situ
Not invade basement membrane non invasive dysplastic
85
Bicalutamide
Androgen antagonist
86
Athletes foot
Cotrimazole
87
Dengue
Saddle back fever 3-14 days flavivirus supportive care Female Aedes Mosquito
88
Lyme
Borrelia Burgdorferi
89
Widespread fungal infection
Terbinafine
90
Lesihmaniasis
Splenic aspirate Amphotercin B
91
Tapeworm
Taenia Saginata
92
AML
myeloid precusor young or very old white and neutorphil splenomegaly
93
MM
Large monoclonal bands
94
CLL
Adult common leukaemia
95
Bind free HB in blood strean
Haptoglobin
96
Renal failure
warfarin
97
Rasburicase
prophylaxis tumour lysis syndrome
98
Reverse doac
Idarucizumab
99
SCID
Common gamma chain defect IL-2RG
100
Mast cell
Mast cell trypstase
101
Liver proteins produced in response to infection
Acute phase proteins
102
Ritonavir
Protease inhibitor
103
Hyperkalaemia
Bradycardia P wave depression Tall peaked t waves
104
Polarised light Gout
Orange
105
Causes of rasied anion gap
Glycols Oxoproline lactate methanol aspirin renal failure ketoacidosis
106
Cyanide antidote
hydroxycobalamin AV block
107
Cholestyramine
Break down cholesterol
108
First line for prostate cancer
Docetaxel then radical prostateectomy
109
Waxy casts
Chronic renal disease
110
Focal segmented glomerulnephritis
Thickened antibody complexes scarring t2dm
111
Membranous GN
proteinuria hep B spikes - subepithelial
112
Area of regrowing tissue
Pseudopolyp
113
Lithium
Ventirular anesuryms
114
oestrogen receptor
Invasive breast carcinoma
115
Influenza
Oseltamvir
116
Chancroid painful ulcers
Haemophilus Ducreyi
117
Tinea
Potassium hydroxide
118
Legionella pneumophilia
Plumbers lung doxycycline
119
Wood lamp orange hypopigmentation
Pityriasis versicolor
120
Uncooked chicken
staph aureus
121
not react to light
Argyll robertson pupil
122
Leptospirosis
farmer jaundice subconjunctival haemorrhage
123
Macrolide
50s ribosome
124
Listeria monocytogenes
tumbling motility and rockets
125
agalactiae
b haemolytic strep
126
Schwann diamond
neutropenia pancreatic dysfunction
127
M3 subtype AML
All trans retinoic acid
128
Essental thrombocytosis
Acute myeloid leukaemia
129
Heparin induced thrombocytopaenia
VTE noraml liver, no immune cause pro thrombin time 4t score rapid anti coag - bilvariudin
130
Ventoclax
BCL2 inhibtor - CLL increase lymphocyte apoptosis
131
Protein C & S synthesis
Protein C & S
132
Eosinophil
Bi lobed
133
basophil
Large blue specks
134
Lymphoma and translocations please
F - 1418 B - 814 - cmyc M - 1114 CML - 922 APMl - 1517 = All trans retinoic acid
135
NADPH oxidase
CGD
136
Granulomatosis with polyangitis
type 2
137
Common variable immuno deficieny
normal human Ig for life
138
T cell proliferation and cell act on
IL2 CD4
139
B agammaglobinaemia
normal human Ig
140
T helper 2
Allergies
141
Coeliac
Protein losing enteropathy
142
Doltuegravir
Integrase inhibitor
143
Osteomalacia
Looser zones Pseudofractures
144
Men
Autosomal dominant
145
Osmolality
lab - calculated
146
TCAs
Overdose - heart block
147
Renal tubular acidosis
hypokalaemia
148
Sarcoidosis
1 alpha hydroxylase
149
Addisons
metabolic acidosis coeliac and low BP
150
Fanconi
proximal not work renal tubules glycosuria low phosphate and high urea
151
Fat necrosis
trauma mass with marking s
152
Adenocarcinoma
most commmon lung
153
Invasive ductal
most common breast
154
Acute interstiital nephritis
Drugs
155
PSC
p-anca
156
Syphilis
Jarsch Herxheimer reaction give pred
157
Sinusitis
Pen V
158
Visceral leishmaniasis
Amp B
159
Blue under woods lamp
Tinea versicolor
160
Molludum contagiosum
kaposis sarcoma
161
Severe malaria
10% parasite level
162
Scarlet fever
Strep pyogenes
163
Diamond blackfan
cleft lip erythroid precursor
164
Lymphocyte
blue cytoplasm RBC size giant nucleus
165
Warfarin inhibitirs
Vit K epoxide reductase
166
Opsonisation
bind to bacteria allow phagocytosis
167
Zidovudine
NRTI
168
IgE
Radioallergosorbent test
169
IL6
Tocilizumab
170
Cyclophosphamide
B cell
171
Lomitapide
MTP inhibitor LDL lowering
172
Type 1 renal tubular acdiosis
metabolic hypo K renal stones not secrete hydrogen type 2 - moderate - hco3 type 4 - hyperk and low aldosterone
173
Raised ALP
Biliary obstruction
174
Most common cause of renal failure
Diabetes
175
TTP
Thrombotic thrombocytopenic purpura HA low plateltes stroke
176
Radiopaque renal stone
Magnesium ammonium phosphate
177
Casts in urine
nephrotic syndrome
178
Stroke
Ct head non contrast
179
Acantholysis
loss of desmosomal connections between cells pemphigus vulgaris
180
HGF2
Trastuzumab - breast cancer
181
Izoniazid
Peripheral neuropathy
182
Strep
Blood agar
183
Beef tapeworm
taenic solium
184
3rd trimester uti
ceflexin
185
Fluroquinolones
Ciprofloxacin
186
Doxyclcin
Tetracycline
187
72 hr fever pattern
Plasmodium malariae
188
Lowenstein jansen
TB
189
Glycopeptide
Vancomycin
190
Pyrazinamide
Hyperuricaemia
191
Hodgin staging
PET-CT scan
192
Hepcidin
ferroportin inhibit
193
AML
Auer rods
194
CLL
smudge cells
195
Burkitts
c myc 814 lots of phagocytose lymphocytes
196
Sickle cell
Howell jolly
197
IV IG
give if platlet count raised quickly
198
3 months
Unprovoked DVT treatment
199
monocyte
3 x RBC, kidney shaped nuclues
200
Monitor what with unfractioned heparin
APTT AT111
201
increased pt count
prednisolone
202
Warfarin
decrease protein c & S
203
Hookworm
IDA
204
D-dimer
fibrin degradation
205
Prphyria
Haem synthesis
206
Andexanat Alfa
Rivaroxaban antidote
207
Essential thrombocytosis
rasied megaK platelets raised increased stroke
208
PT
extrinsic and intrinsic pathways
209
mantoux test crohns
Tb interacts with TNF alpha inhibtors hence it can activate TB
210
T helper
CD3 CD4
211
Rejection
sensitise beforehand
212
HIV
HIV bind to CD4 expose gp41 - fuse with gp120 then CCR5
213
GvHD
organ vs recipient cells and tissues
214
Polyarteritis Nodosa
small aneurysms rosary bead appearance
215
CD14
Monocytes
216
EGwP
fever/rash small vessel vasculitis p-anca corticosteroids
217
IgA
breastmilk
218
Lomitapide
MTP LDL blocks VLDL
219
Type 3 hyperlipoproteinemiea
ApoE2
220
NPC1L1
Ezetimibe gut absorber blocks blood cholesterol
221
Polycystin 1
PKD
222
Most common renal cancer
renal cell carcinoma
223
PE
DVT
224
Post strep glomerulonephritis
immune complex post infection
225
Pink frothy suptum
Pulmonary oedmea
226
ALP
Ischaemic marker
227
Bad prognostic breast cancer
HER2 Invasive breast carcinoma
228
Renal cell cancer
flank haemturia mass on one side
229
Oesphageal candidiasis
HIV test
230
Cutaenous lesihmanisasis
volcano like lesion
231
Oseltamvir
Influenza neuroamindase
232
Sandfly
leishmaniasis
233
Methenamine silver stain
aspergillosis
234
Splenic aspirate
Leischmaniasis
235
Taenia saginata
beef tapeworm
236
potasssium hydroixde
fungal infection
237
SCD
salmonella bacteraemia
238
Coxiella
multi lobar penumonia
239
Non sedating antihistamine
anaphylaxis transfusion
240
Coeliac
Diabetes HLADQ2
241
NK
Innate lymphocyte no receptors
242
Granulmatosis with polyangitis aka wegeners
rapid decline in kidney function nosebleeds c-anca
243
B12
pernicious anaemia
244
Speckles homogenous
anti dsdna - homogenous anti centromere - speckled
245
ILs
IL1 - fever IL6 - Tolizumab CRP - C1q
246
rate limiting step in de novo syntheis
PAT
247
gout in red light
orange
248
cyanide poisoning
hydroxycobalamin
249
Papillary muscle damage
mitral regurgitation
250
Pemphigus vulgaris
blister in mouth diabetes acntholytic cells basal kertinocytes - basment membrance
251
Signet ring sign lung
Bronchiectasis
252
Most deadly cancer
lung
253
Dark urine
myoglobin
254
Group A strep
acute postinfectious glomerulonephritis
255
Membranous glomerular disease
pred thickening
256
Brown casts
cast nephropathy acute tubular necrosis
257
Alports
giberts
258
Chronic cystitis
Squamos cell carcinoma
259
Hereditary haemochromatosis
low TIBC high transferrin high ferriting family history
260
bronchiectasis
tram track signs
261
Relapsing remiting happens where
Multiple sclerosis
262
Aschoff bodies
heart failure in rheumatic disease
263
Plasma cell
secrete Ig
264
HLA DR3
graves sle
265
Sjogrens
MALt
266
TACO
transfusion associated circulatory overload
267
Polyarteritis nodosa
hep b sural nerver roasry bead
268
NRTIs
zidovudine and abacavir
269
Catalase organisms
e coli and listeria CGD
270
Oral candida
Common immunodeficiency
271
Thryoid cancer
anti-thyroglobin
272
Steroids
acute leukocytosis
273
Subdural
crescent shaped
274
Acute intersitial nephritis
white cell casts eosinophilia antibiotic use
275
ILD
high resolution CT
276
Lambert eaton
SSLC
277
Dilated left atrium
bifid p waves failed cardioversion
278
heart and liver
AST - aspartate aminotransferase
279
LFTs
ALP > ALT - cholecystisi ALT - toxins AST > ALT - alcohol Pregnant - ALP and fracture
280
SLE
rapidly progressive glomeruonephritis
281
Kostmanns
congential neutorpenia granulocyte colony stimulating factor increased neutorphil levels
282
Diffuse CSS
more than arms and legs
283
HIV
retroviridae
284
CART
chimeric antigen receptor t cells tisagenleculeucal leaukamia large bc cell cytokine release
285
Alemtuzumab
CD52 and all t cells
286
IgA
4 binding sites
287
Brutons agammaglobinemia
Low Bcell and Tgs BTK 6 monhts breastfedding normal IvIg for life
288
Mantoux
tuberculin purified protein derivative
289
Autimmune thrombocytopenic purpura
gpIIb / IIIa
290
RA
rasied platelets and ATP
291
Most common non hodgkin lymphoma
Diffuse Large B cell lymphoma
292
IgH variable mutation good or bad
Good for CLL
293
CML
raised WBC, neutrophil and myelocyte prone to infection
294
Carbimazole
bone marrow suprresion
295
Myelodysplastic syndrome
hypogranula lobed neutrophiles cytopenias infections becasue of neutropenias
296
Oral Cavity cancer
SCC
297
Hemoglbinuria, renal cell carcinoma and cysts on pancreas
Von Hippel Lindau Syndrome
298
Virus for nephritis
BK
299
Sjorgens
Lymphocytes
300
Large thin walled cysts
PCKD
301
HOCM
Hypertrophic cardiomyopathy
302
Smear cell
CLL
303
Heart failure
Iron overload
304
Moulds
Alfatoxin HCC
305
High ALP
Cholestasis
306
Traveller
Salmonella typhi
307
Low Co2
BDZs
308
Low calcium by itself
Hypoparathroidism
309
Bad hepatitis in pregnancy
Hep E
310
CAH
21- hydroxylase def
311
SLE symptoms
rash, ulcer, hair loss
312
HIV main virus
cryotcoccus rapid antigen test
313
eosinophil interleukin
IL5
314
Blood culture what condition
endocarditis