Immuno - Antibodies

Question 1

Antiphospholipid Syndrome (APS)

Answer 1

anti-cardiolipin, lupus anticoagulant

Question 2

AI hepatitis

Answer 2

Anti-smooth muscle antibody

Question 3

Churg-Strauss/eGPA

Answer 3

p-ANCA

Question 4

Coeliac

Answer 4

anti-Tissue Transglutaminase Antibody (TTG), Anti-Endomysial Antibody (AMA)

Question 5

Dermatitis herpetiformis antibody and association

Answer 5

anti-endomysial (think coeliac associated)

Question 6

Dermatomyositis

Answer 6

Anti-Jo1

Question 7

Diffuse scleroderma

Answer 7

Anti-scl70 (topoisomerase)

Question 8

Limited scleroderma (CREST)

Answer 8

Anti-centromere

Question 9

Goodpasteur’s

Answer 9

anti-GBM

Question 10

Graves

Answer 10

anti-TSHr (stimulatory)

Question 11

Hashimoto’s

Answer 11

anti-thyroglobulin and anti-thyroid peroxidase

Question 12

Microscopic polyangitis (MPA)

Answer 12

p-ANCA

Question 13

Myasthenia Gravis

Answer 13

Anti-ACh receptor

Question 14

Pernicious anaemia

Answer 14

anti-parietal cell and anti-intrinsic factor

Question 15

Polymyositis

Answer 15

Anti-Jo1

Question 16

PBC

Answer 16

Anti-mitochondrial antibodies

Question 17

RA

Answer 17

Anti-Cyclic Citrullinated Peptide (most specific), Rf

Question 18

SLE antibodies

Answer 18

Anti-dsDNA (most specific)

Anti-Ro, La, Sm (anti-ENAs)

Question 19

Sjögrens

Answer 19

Anti-Ro, Anti-La (anti-ENAs)

Question 20

T1DM

Answer 20

Anti-Glutamate Decarboxylase and Pancreatic ß cells

Question 21

What is the most specific marker for Rheumatoid arthritis:

a. Anti-nuclear antibodies
b. Anti-cyclic citrullinated protein
c. Rheumatoid factor
d. Tissue-transglutaminase antibody
e. Anti-dsDNA antibodies

Answer 21

b. Anti-cyclic citrullinated protein