Histopath Flashcards
Oesophageal cancer with smoking and alcohol 20 cm down
Squamous cell carcinoma
Most common breast malignancy
Invasive ductal
E-cadherin related
Invasive Ductal
Fibroepithelial tumour with stromal elements (breast)
Phylloides
Pain at the END of micturition + loin to groin pain
Renal calculi
Man with AF develops fever, N&V, and pain in right loin
Renal infarct (AF-> clots)
Cancer with keratin and intercellular bridges (desmosomes)
SCC
Transitional cancer - which organ?
Bladder
Ovarian cancer - most common + psammoma bodies
Serous cystadenoma
Sarcoidosis changes in LNs
Granulomas
What is deposited in kidneys in MM?
AL amyloid or IgG light chains
What material is seen in the vessel of a paitent with an MI due to burst atheroma? (embolus/thrombus/atheromatous plaque)
Thrombus
What would you see in scar 1 week post op?
Granulation tissue (?)
54 yo, fever, weakness, hyperCa, painless haematuria
Renal Cell Carcinoma
Pain at end of micturition and fever
UTI
Bilateral oedema, oliguria, ,red cell casts
Nephritic syndrome
Kidney changes in T1DM
Renal sclerosis
Radiosensitive cancer of the testicle in young man + white/smooth appearance
Seminoma
Bladder cancer + schistosomiasis
SCC
Breast: 55yo, bloody nipple discharge, branching fibrovascular cores, bland epithelium
Duct papilloma (AKA Intraductal papilloma) - benign
Artichoke like breast lump
Phyllodes
Stellate pattern of glandular tissue surrounding central scar
Radial scar (resembles carcinoma on mammogram)
Keritanizing squamous epithelium in smokers breast
Periductal masitits (not lactation related)
Breast mass, aspirate brown fluid, cysts
Fibrocystic disease
red, roughened, ulcerated nipple
Paget’s of the nipple
Microcalcifications of mammography
Ductal carcinoma in situ
Sheets of atypical cells with lymphocytic infiltrate (breast)
Basal like carcinoma
Multiparous, thick white secretions from nipples
Duct ectasia
Lung cancer with paraneoplastic syndromes (e.g. ACTH)
Small cell carcinoma
Plumber, thickened pleura
mesothelioma
ship worker pleural plaques
asbestos
red rusty sputum
strep pneumonia
Pattern of lung injury in a1at deficiency
emphysema (often in non smokers)
Aggressive LCa responds to chemo
Small cell
Common in women and non-smokers (Lung ca)
Adenocarcinoma
Smokers + SIADH
Small cell lung cancer
Mutations in lung cancer: KRAS
adeno or squamous = poor prognosis, do not respond to tyrosine kinase inhibitors
Mutations in lung cancer: EML4-ALK
adenocarcinoma
Mutations in lung cancer: EGFR
adenocarcinoma
Mutations in lung cancer: ERCC1
NSCLC - poorer response to cisplatin
Howships lacunae associated with which cell
Osteoclasts
20yo with lytic lesion in the diaphsis of his leg - the pain is alleviated by aspirin
Osteoid Osteoma
Liver ANA pos with lymphocytic infiltrate
AI hepatitis
PBC
AMA+, cirrhosis, high ALP, granulomas, A/W autoimmune conditions
PSC
Symptoms? Histological appearance? Complications?
Beaded appearance, UC, onion skin fibrosis, can progress to cholangiocarcinoma
Lower GI polyps not associated with cancer risk
Hamartomatous (also seen in Peutz-Jeghers Syndrome )
84yo woman, acute cramp like abdo pain, oedematous thickening of bowel wall, areas of necrotic ulceration confined to mucosal layers, AF
Ischaemic colitis (often in watershed areas i.e. rectosigmoid or splenic flexure)
Signet ring cell cancer
Adenocarcinoma in the ovaries–> tends to be from gastric (or lower GI)
Krukenberg
Signet ring cell carcinoma from stomach in ovaries
Pernicious anaemia associated with what cancer
Gastric cancer (?MALT)
Cancer of the pancreatic duct
Ductal adenocarcinoma
Pancreatitis and IgG deposition
AI Pancreatits
Rare pancreas tumour in children
Pancreatoblastoma
Mass following acute pancreatitis
Pseudocyst
Chronic pancreatitis macro sign on laparoscopy
White specks around and on pancreas
Which Creutzfeld-Jakob disease starts with psychiatric symptoms when younger, then motor symptoms?
Variant Creutzfeld-Jakob disease
b-amyloid plaques
Alzheimer’s disease
Epileptic, freckles, optic nerve tumour, bumps on skin
NF1
Mass under dura mater compressing parietal lobe
Meningioma
Capillary loops surrounded by epithelial cells
AV malformation
HIV, raised ICP, new onset epilepsy
Cryptococcus/toxoplasmosis
Raised AFT testicular tumour
Teratoma (germ cell tumours) - are CHEMOsensitive
Painless ulcer, snail track ulcers in mouth
Syphilis
Thyroid cancer with RET mutation
Medullary
Calcitonin staining thyroid
Medullary (+MEN2+Parafollicular C cells)
Cystic lesion with papillary architecture/clear cytoplasm in thyroid
Papillary
Tumour which secretes oestrogen
Granulosa-theca cell tumour
Fibroma (Ovarian) association
Meig’s syndrome (ascites and pleural effusion)