pat Flashcards by Kush Sharma

Q

BCR ABL
Gene product
Assoc tumor

A

Tyrosine kinase

CML, ALL

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Q

BCL-2
Gene product
Assoc tumor

A

Anti-apoptotic

Follicular and undifferentiated lymphoma

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Q

BRAF
Gene product
Assoc tumor

A

Serine-threonine kinase

Melanoma/non-Hodgkin lymphoma

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Q

c-kit
Gene product
Assoc tumor

A

Cytokine receptor

Gastrointestinal stromal tumor

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Q

c-myc
Gene product
Assoc tumor

A

transcription factor

Burkitt lymphoma

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Q

Her2/neu

A

tyrosine kinase

Breast. ovarian, gastric carcinomas

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Q

L-myc
gene prod
assoc tumor

A

trans factor

lung tumor

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Q

N-myc
gene prod
assoc tumor

A

trans factor

neuroblastoma

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Q

RAS

gene prod

A

GTPase

colon, lung, pancreatic cancer

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Q

RET
gene prod
assoc cancer

A

tyrosine kinase

men 2a/2b, medullary thyroid cancer

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Q

APC assoc tumor

A

Colorectal cancer

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Q

BRCA1/BRCA2
assoc tumor
gene product

A

breast and ovarian cancer

dna repair protein

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Q

DCC
assoc tumor
gene product

A

colon cancer

deleted in colon cancer

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Q

DPC4/SMAD4
assoc tumor
gene product

A

pancreatic cancer

deleted in pancreatic cancer

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Q

MEN1
assoc tumor
gene product

A

MEN 1

menin

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Q

NF1
assoc tumor
gene product

A

NF1

Ras GTPase activating protein (neurofibromin)

Q

NF2
assoc tumor
gene product

A

NF2

merlin protein

Q

p16
assoc tumor
gene product

A

melanoma

cyclin dependent kinase inhibitor 2A

Q

p53
assoc tumor
gene product

A

human cancer, li fraumeni

transcription factor for p21 blocks G1–>s phase

Q

PTEN

assoc tumor

A

breast cancer, prostate, endometrial

Q

TSC 1

A

tumberous scloerosis

hamartin protein

Q

TSC 2

A

Tuberous sclerosis

tuberin protein

Q

VHL

A

VHL RCC

inhibits hypoxia inducible factor 1a

Q

WT1/WT2

A

Wilms tumor (nephroblastoma)

Q

CA 15-3/27-29

A

Breast cancer