MSK

Question 1

Osteoblasts derived from?

Answer 1

mesenchymal stem cells in periosteum

Question 2

Osteoclasts derived from?

Answer 2

monocytes/macrophages

Question 3

What is specific marker for osteoblastic activity?

Answer 3

Bone specific alkaline phosphatase

Question 4

What is specific marker for osteoclastic activity?

Answer 4

Tartrate resistant acid phosphatase ,urinary hydroxyproline, and urinary deoxypyridinoline

Question 5

What auto dominant mutation disease is homozygosity lethal in?

Answer 5

Achondroplasia

Question 6

Artery affected most commonly in avascular necrosis

Answer 6

Because femoral head is most commonly affected, due to insufficiency of medial circumflex femoral artery

Question 7

What is MSK path most commonly associated with giant cell arteritis?

Answer 7

Polymyalgia rheumatica

Question 8

What layer undergoes hyperplasia in acanthosis nigracangs?

Answer 8

Stratum spinosum

Question 9

Defect in what has been thought to be the cause of atopic dermatitis?

Answer 9

filaggrin (binds keratin to epithelial cells)

Question 10

What layer does staphylococall scalded skin syndrome affect?

Answer 10

destroyes keratinocyte attachements in stratum granulosum only