Pasteurella Flashcards
What is the wommon habitat of Pasteurella multocida?
Common worldwide
Upper respiratory tract
Oral cavity (especially in dogs & cats)
Which subspecies of Pasteurella is the most common cause of fowl cholera?
Pasteurella multocida subspecies multocida
Besides Pasteurella multocida subspecies multocida, what are the other 2 subspecies?
Septica
Gallicida
What is Pasteurella’s appearance when stained with Giemsa or Wright’s stains?
Bipolar
True or False:
- Some fresh isolates of Pasteurella multocida are encapsulated.
- Capsule composition varies according the Type, but always consist of a polysaccharide.
- TRUE
- TRUE
What are the 2 typing systems for Pasteurella multocida?
Capsular typing
Somatic antigen typing
Capsular Type A is a component of ____ _____ ____ in cattle, along with which you may see ____ in the lungs.
Capsular Type A is a component of SHIPPING FEVER PNEUMONIA in cattle, along with which you may see ABSCESSES in the lungs.
True or False
Type A:5 is most commonly associated with the shipping fever pneumonia in cattle.
FALSE
Type A:3
Explain the immunization protocol of cattle for Pasteurella multocida TYPE A
Bacterins are rutinely used in preconditioning of feeder calves. Benefit is doutful, especially once animals are stressed. Must have 2 or more doses.
Modified live vaccines have so far proven too toxic or ineffective.
What polysaccharide makes up the capsule composition of P. mult Type A?
Hyaluronic acid
What are the 5 different capsular types for Pasteurella multocida?
A
B
D
E
F
How many somatic antigens are there for Pasteurella multocida?
16
True or False
- Type B has been isolated from bisoin in Yellowstone National Park and Canada.
- This disease could pose a threat to the cattle in the U.S.
- Type E has been isolated from animals in the U.S.
- TRUE
- FALSE - Does not appear to be a threat to cattle in the U.S.
- FALSE - Type E is only in Africa
What type of disease do Types B and E cause?
Hemorrhagic septicemia
Type A causes what disease in swine?
Pneumonia
Type D causes what disease in swine?
Atrophic rhinitis
Which virulence factor of Pasteurella multocida causes the atropic rhinitis in swine?
Cytotoxin
What are 3 systemic effects of the Type A cytotoxin?
- Depressed growth
- Hepatotoxicity
- Alteration of bone growth
In association with Pasteurella multocida, the cytotoxin is a single polypeptide that binds to host cell ganglioside receptors.
Once inside the host cell, the toxin activates what?
G protein
Causes an increase in osteoclastic activity and a decrease in osteoblastic activity
Type A is the cause of what 2 disease in sheep?
Pneumonia
Mastitis
Which Type(s) of Pasteurella multocida cause snuffles in rabbits?
Which is the most common cause?
Type A (most common)
Type D
What is perhaps the NUMBER 1 cause of economic loss to the poultry industry in the U.S.?
Pasteurella multocida TYPE A
Which subspecies are most commonly found in human infections?
Subspecies multocida
Subspecies septica
In what percentage of cat mouths is P. mult found?
90%
