Bacillus Flashcards
All bacillus species are motile via flagella, except what?
Bacillus anthracis
The growth of Bacillus anthracis is inhibited by ____, such as is found in dead carcasses.
CO2
- What is Bacillus anthracis resistant to?
- What can kill Bacillus anthracis?
- Resistant to:
- Phenol disinfectants
- Boiling for 20 minutes
- Killed by:
- Formalin
- Autoclaving
***THE VEGETATIVE FORM IS READILY KILLED***
Bacillus anthracis produces a three-part toxin. What are the 3 parts of that toxin?
Lethal factor
Edema factor
Protective antigen
Toxin production is dependent upon the presence of a large plasmid which can be eliminated by passage at _____ or exposure of culture to _____.
Toxin production is dependent upon the presence of a large plasmid which can be eliminated by passage at 42.5 degrees C or exposure of culture to antibiotic novobiocin.
- Which part(s) of the 3 part toxin act a B (binding) unit?
- Which part(s) of the 3 part toxin act as an A-subunit?
- Protective antigen
- Edema factor & lethal factor
Which toxin has the following action:
Attaches to the cell receptor and undergoes proteolytic cleavage. By remaining bound to the cell, this toxin serves as a docking station for binding of other toxin parts.
Protective antigen
What does edema factor activate?
Adenylate cyclase
What does lethal factor cleave?
Kinase involved in signal transduction in CD4+ T-lymphocytes and fibroblasts
Which toxin inhibts IL-2 production and proliferative responses in the CD4+ T cells, thereby blocking fuctions that are pivotal in the regulation of the immune response?
Lethal factor
What is the Bacillus anthracis capsule composed of?
Poly-D glutamic acid
Which organism is distributed worldwide, especially in alkaline soils with high N content with alternating flooding and drying periods?
Bacillus anthracis
