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1MRCP Part 1 > Past Papers > Flashcards

Past Papers Flashcards

1
Q

What is associated with poor prognosis in RA?

A

Anti CCP antibody

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2
Q

Pure sensory neuropathy - diagnosis?

A

Uraemic neuropathy
Not GBS as no motor involvement

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3
Q

What is the mechanism of action of irinotecan?

A

Topoisomerase inhibitor

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4
Q

Multiple cranial nerve palsies - where is the lesion?

A

Cavernous sinus

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5
Q

What exhibits zero order kinetics?

A

Aspirin - salicylates

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6
Q

Congruous vs incongruous quadrantopias

A

CRIT
Congruous - radiations
Incongruous - tract

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7
Q

Urine findings in acute tubular necrosis (2)

A

High urine osmolality
High urine sodium - tubules unable to reabsorb

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8
Q

Where are parietal cells found?

A

Fundus of stomach

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9
Q

What is the precursor to endogenous NO?

A

L-arginine
NO then causes an increase in cGMP

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10
Q

What drug is associated with IUGR

A

Bisoprolol (B blockers)

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11
Q

Jaundice
Ascites
Weight gain
Sudden onset
Differential?

A

Veno-occlusive event in liver e.g. Budd Chiari

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12
Q

Management of nephrogenic DI secondary to lithium

A

Use thiazide diuretic, reduces the urine output

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13
Q

Precursor to cortisol

A

11 deoxycortisol

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13
Q

Basal meningeal enhancement + bacterial CSF

A

TB meningitis

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13
Q

Concern with TEN

A

VTE - fluid loss, resulting hyperviscosity

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13
Q

Horner’s syndrome
- course of neurones

A

1st order - hypothalamus to cervical spine
2nd order - runs along sympathetic chain to superior cervical ganglion
3rd order - superior cervical ganglion to cavernous sinus (via internal carotid artery)

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14
Q

Genotype in severe A1-antitrypsin deficiency

A

PiZZ

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14
Q

Management of botulism

A

Anti-toxin

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14
Q

Management of cyanide poisoning

A

Amyl nitrate

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15
Q

What is tobramycin an example of?

A

Aminoglycoside (30s subunit inhibition)

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15
Q

Management of active lupus disease + renal involvement

A

MMF better than HCQ

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15
Q

Management of hip osteonecrosis + young patient

A

Decompression and grafting
THR as a last resort

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15
Q
A
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16
Q

What is fear of germs?

A

Mysophobia

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16
Q

Management of nausea in bowel obstruction

A

Haloperidol

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17
Q

Grapefruit juice is a…

A

CYP3A4 inhibitor
Reduces metabolism - greater toxicity effect of medication

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17
Q

What is the pathogenesis of serotonin syndrome?

A

Impaired serotonin reuptake

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17
Q

Diagnosis of MND

A

Electromyography is helpful

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17
Q

Management of persistent air leak in PTX

A

Video guided thorascopic pleurodesis
Talc pleurodesis most helpful in malignancy

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17
Q

Fixed S2 - ostium secundum vs ostium primum

A

Ostium secundum is more common
Both cause fixed S2

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17
Q

Number needed to treat?

A

1/
control event rate - experimental event rate

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17
Q

How do B cells switch which immunoglobulins they produce?

A

Switch the constant heavy chain region

17
Q

What is the risk of celecoxib?

A

Less risk of GI haemorrhage than other NSAIDs
Risk of worsening cardiac failure

17
Q

1st line management in ADPKD

A

ACEI

17
Q

Rapid reversal of warfarin e.g. urgent surgery

A

PCC - offers more rapid reversal than vitamin K

17
Q

Gene association with
- breast/pancreatic/prostate cancer

A

BRAC2
(BRAC1 not pancreatic cancer as much)

18
Q

What is the pathophysiology of haemoptysis in
- bronchiectasis
- PE

A

Bronchiectasis = capillary engorgement
PE = pulmonary parenchyma necrosis

18
Q

Assessment of function post stroke

A

Barthel Index
Does Bart need hel(p) following his stroke?

18
Q

What measure of lung function is reduced in obesity?

A

ERV

18
Q

Feature in CKD that contributes to iron deficiency anaemia

A

Increased hepcidin
= hepcidin reduces oral iron absorption

18
Q

Anti-hypertensive to avoid in lithium use

A

ACEI/ARB - can increase lithium toxicity

18
Q

1st line anti-HTN in pregnancy

A

Labetalol
(nifedipine is second line)

18
Q

Vomiting - determining between bulimia and anorexia

A

Bulimia - if BMI >17.5
If below that = anorexia

18
Q

Type of receptor
- insulin

A

Tyrosine kinase

18
Q

What has the greatest influence on O2 inspiration?

A

Flow rate of O2 (think HFNC - doesn’t matter about the mask, all about the flow)

18
Q

Management of pericarditis

A

Colchicine
Anakinra
Pericardectomy

18
Q
A
18
Q

Investigation for confirmation of renal artery stenosis

A

MR angiography

18
Q

Idiopathic pulmonary hypertension classification

A

Group 1

18
Q

What in management of pulmonary hypertension can reduce sperm count?

A

Endothelin receptor antagonist

19
Q

What gallbladder stones are people with sickle cell prone to?

A

e.g. sickle cell or hereditary spherocytosis
= chronic haemolysis
= bile pigment stones due to increased bilirubin

19
Q
A
19
Q

Bronchiolitis obliterans
- lung function pattern
- symptom

A

Obstructive
Breathlessness

19
Q
A
19
Q

Management of lewy body dementia

A

Donezepil
- poor response to levodopa

19
Q
A
19
Q
A
19
Q

Statistical test for crossover trial

A

Paired T test

19
Q

Colon cancer + no polyps at young age =

A

= HNPCC
MSH2 gene

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21
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22
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1MRCP Part 1 (20 decks)

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