PASSPORT NAS TI7IT Flashcards
What order Adrenal Insufficiency is Addison’s?
Primary Adrenal Insufficiency
What is Addison’s Disease, aka what causes it?
When adrenal glands are damaged so don’t produce enough steroid hormones (cortisol + aldosterone)
What are the cause of primary adrenal insufficiency aka Addisons? (4 things)
- AI (90%)
- Infection (TB)
- Cancer (adrenal gland cancer)
- Trauma (from surgery)
Why should you investigate standing blood pressure for Addisons?
Bc with lack of cortisol, you will get orthostatic hypotension
Why is ACTH high in Primary Adrenal Insufficiency?
Because low cortisol –> -ve fdbk –> Pituitary releases more ACTH
What CF is caused by high ACTH in Primary Adrenal Insufficiency?
Bronze hyperpigmentation of skin
What does a Short Synacthen test tell you? (GOLD STANDARD)
- Primary = NO increase in cortisol* (bc adrenal glands r clarted)
- Secondary / Tertiary = increase in cortisol (bc its da pituitary / hypothalamus that r clarted)
* = Cortisol should increase by more than double baseline if normal, if not = primary AI
What is are 3 Mx options for Adrenal Insufficiency? (3 things)
Steroid replacement
1. Hydrocortisone (to replace cortisol)
2. Fludrocortisone (to replace aldosterone)
(But remember in Addisonian crisis only replace hydrocortisone)
3. If in crisis, give fluids and dextrose as well
What are conservative Mx options for Addisons? (4 things)
- Avoid stress
- Healthy diet
- Stay hydrated
- No alcohol
How does High pH effect Hb?
High pH, Hb hugs (binds) oxygen
(Low pH, Lets go of oxygen) (Bohr effect)
How does Cold Temperature effect Hb?
Cold Temperature, Hb Clings to Oxygen
(hot temperature is the opposite obv)
What are the smoking cessation drugs? (4 things)
- Nicotine Replacement Therapy (NRT): Low dose nicotine in gum / patches
- Bupropion: antidepressant, causes anhedonia to smoking lol (aka less craving)
- Varenicline: fake nicotine
- Clonidine: anti-HTN
What are the CI for the smoking cessation meds?
- NRT: Recent MI / uncontrolled HTN
- Bupropion: pregnant / breastfeeding
- Varenicline: pregnant / breastfeeding
- Clonidine: recent MI
Why are MTX doses higher for Cancer than for RA? (3 things)
- Target of Tx: Cancer is killing cancer cells + shrinking tumours, while RA is just reducing inflamm + slow disease progression
- Route: Cancer is IV, so higher doses available, RA is oral so only smaller doses available
- Side fx: MTX has bad side fx such as liver damage, so benefits outweigh risk in cancer more than for RA for higher doses
What are some Extra articular features of RA?
- Eyes: scleritis / episcleritis / uveitis
- Vasculitis
- Pericarditis
- Interstitial Lung Disease (ILD)
What are the early XR findings of RA? (4 things)
- Could be normal
- Loss of joint space
- Juxta-articular osteopenia
- Soft-tissue swelling
What are the late XR findings of RA? (2 things)
- Bony erosions
- Subluxation (partial dislocation of joint)
What are the borders of Femoral triangle?
S-AL-IL (zay Khalil bs SALIL)