PASSPORT FINALE Flashcards
What does Complete Heart block look like in ECG?
(complete disassoc between P n QRS)
Where are the Purkinje fibre / Bundle of His in diagram of heart cut in half?
Where are Myocardium, Endocardium, and Purkinje fibres in Histology?
Where are Myocardium, Endocardium, and Purkinje fibres in Histology, again?
What is the definition of Orthostatic hypotension? (2 options)
- Drop in Systolic by 20 // OR
- Drop in Diastolic by 10
(within 2-5 mins of standing)
What medications can cause Heart Block? (7 things)
HF meds + more
1. Amiodarone
2. Beta blockers
3. CCB
4. Digoxin
5. TC antidepressants
6. Opioids
7. Antihistamines (bc drowsiness)
Apart from Orthostatic hypotension, what can cause LOC? (9 things)
- Dehydration / No food
- Standing for long time
- Vasovagal
- Hypoglycaemia
- Anaemia
- Arrhythmias
- Valvular HD
- Infection
- Anaphylaxis
(Dear Sam, Very Happy After A Vacation In Australia)
List malignant causes of cervical lymphadenopathy? (6 things)
- Lymphoma
- Leukaemia
- Thyroid cancer
- Nasopharyngeal cancer
- Squamous cell carcinoma (skin cancer)
- Metastatic cancer (spread to lymph nodes)
(Listen, Lumps in The Neck Signal Malignancy)
Give 4 causes of lumps in the neck apart from Lymphoma?
- Thyroid nodule
- Lipoma
- Salivary gland tumour
- Metastatic cancer (spread to lymph nodes)
What are 2 B symptoms associated with hodgkins lymphoma? (3 things)
- Fever
- Night sweats
- WL
Give a description of Reed Sternberg cells and then the name (reed sternberg cells)?
LARGE MULTINUCLEATED CELL, nucleus bilobed? prominent nucleolus?
B lymphocytes mutate into 2 types of cell:
1. Reed-Sternberg cells (large multi-nucleated cells)
2. Hodgkin cells (large mono-nucleated)
(I think question asking to describe unnamed cell, and then next part is to name the cell which is Reed-Sternberg)
How do you stage and assess what cancer it is? (2 things)
- Gold standard investigation for Dx = Lymph node biopsy
- Staging for HL = Ann Arbor Staging system (do CT)
What are the Ann Arbor Stages that you will see on CT? (not a q but write it just so they kno u kno)
- Stage 1: Confined to 1 region of lymph nodes
- Stage 2: In 2+ regions but on same side of diaphragm (above / below)
- Stage 3: In regions above AND below diaphragm
- Stage 4: Spread to NON-lymphatic organs e.g liver / lungs
What do you need to consider before special tests (ct / core needle biopsy)?
- Biopsy = risk of bleeding / inf
- CT scan is ionizing radiation = can increase risk of cancer over time
- Maybe do bloods before to check (low everything in FBC)
Interpret Odds ratio:
- If Odds ratio = 1, then no assoc between exposure + disease
- If Odds ratio more than 1, means positive association, so means exposure causes the disease defo
- If Odds ratio less than 1, means negative association, so means exposure protects against disease
Give 2 immediate + 2 delayed reactions of blood transfusion?
Immediate
1. Acute Haemolytic Transfusion Reaction (AHTR)
2. TRALI (Transfusion Related Acute Lung Injury)
Delayed:
1. Delayed Haemolytic Transfusion Reaction (DHTR)
2. Iron overload
What are 4 types of prolapses?
- Bladder prolapse (cyctocele)
- Uterine prolapse
- Vaginal prolapse
- Rectal prolapse (rectocele)
What are 3 conservative and 3 surgical treatments for prolapses?
Conservative
1. Pelvic floor exercise
2. Pessary (that white ring you saw them put in)
3. Lifestyle: WL, no heavy lifting, treat constipation
Surgical
1. Hysterectomy (uterus)
2. Sacrocolpoplexy (uterus / vagina) (mesh)
3. Ant / Post repair (repairs vagina walls –> treats bladder / rectum prolapse)
4. Rectopexy
What are 2 examinations you need to perform in prolapse and why? (3 things)
- Pelvic exam, including bimanual, and ask pt to cough / squeeze, to see strength of pelvic muslces and ligaments
- Urodynamic studies – to check bladder function + any incontinence
- Rectal exam – n ask pt to cough / squeeze
What are 4 symptoms of prolapses?
- Bulge + feeling pressure in vagina / rectum
- Dyspareunia
- Incontinence
- Frequency / urgency / can’t empty bladder
What investigations should you do for someone presenting with incontinence? (4 things)
- Bladder diary
- Urodynamic testing
- Urinalysis (UTI?)
- Cystoscopy (structural abn?)
What are 4 signs of parkinsons?
- Tremor
- Rigidity (cogwheel)
- Akinesia / Bradykinesia
- Postural instability
What are the MOA of the different Parkinsons meds? (5 things) (M list, not sure if acc q or relation to levodopa / carbidopa q from R list)
- Levodopa = precursor to dopamine, converted to dopamine in brain
- Carbidopa = peripheral decarboxylase inhibitor, stops levodopa being broken down peripherally
- Pramipexole = dopamine agonist, reduce levodopa dose needed
- Rasagiline = MAO-B inhibitor, stop dopamine breakdown in brain
- Entacapone = COMT inhibitor, stops dopamine breakdown peripherally
Why are levidopa and carbidopa used instead of just dopamine for Parkinsons? (4 points)
- Because dopamine can’t cross BBB
- Parkinsons is shortage of dopamine inside brain, so you need to get dopamine to brain
- Levidopa can cross BBB
- But need to give Carbidopa to stop levodopa from being broken down before it reaches brain
Why do Parkinsons pt get choreiform movements? (3 things)
- Bc Levodopa
- Meds taken several times per day
- Fluctuating levels of dopamine throughout day causes chorea, aka levodopa-induced-dyskinesia (invol brief movements)
What is the pathophysiology of Parkinsons? (it’s a fill in gap question) (4 points)
- Parkins is neurodegenerative disorder
- Substantia nigra (in basal ganglia) degenerate
- So no more dopamine produced
- Dopamine controls movement and coordination
(not the acc one in exam but basic pathophys to remember)
down’s
Name 2 tests used for screening other than down’s screening and name the diseases they test for
- AFP (Alpha-fetoprotein) screening = tests for Neural Tube Defects (spinda bifida / anencephaly)
- NIPT (non-invasive prenatal testing) = tests for trisomy 18 and 13 (aka Edwards and Patau syndromes)
What are 4 features of a good screening test? (6 things)
- High sensitivity
- High specificity
- High PPV (positive predicted value)
- High NPV (negative predicted value)
- Reliability (aka can be repeated to give consistent results)
- Cost-effective
What is the difference between Sensitivity and specificity? (M list)
- Sensitivity = ability of a test to correctly identify ppl who have the disease
- Specificity = ability of a test to correctly identify ppl who DON’T have the disease
What are 2 features of Downs syndrome on the picture?
- Slanted upturned eyes
- Flat nose bridge
- Small ears
- Short neck
How does VSD cause tachycpnoea? (4 steps)
- L-R shunt
- Increased blood flow to lungs
- Increases workload on lungs
- RR increases (tachypnoea)
Label the main arteries and veins from the heart?
What are the branches of the aorta? (3 things, from L to R) (not a q, but helping with labelling one above)
- Brachiocephalic artery
- Left Common Carotid artery
- Left subclavian artery
What are the Coronary Arteries? not a q, but helping with labelling one above)
Label the coronary veins? (3 things) (not a q, but helping with labelling one above)