Cancer Formative

Question 1

What is FIRST line for pain mx of painful bone mets?

Answer 1

Radiotherapy

(thought it was 2nd after bisphosphonates, but no its FIRST line)

Question 2

In Paraneoplastic Cushings from lung cancer, what other CF can you get? (clue is in women)

Answer 2

Hirsutism

Question 3

What hormones do breast cancer produce?

Answer 3

Parathyroid Hormone Related Peptide (PTHrp)

Question 4

What is the lymphatic drainage of anal cancer ABOVE the pectinate line?

Answer 4

Internal iliac nodes

Question 5

What is the lymphatic drainage of anal cancer BELOW the pectinate line?

Answer 5

Superficial inguinal nodes

Question 6

What is the MOA of Bisphosphonates?

Answer 6

Inhibit osteoclast activity

Question 7

What meds do you give in Prostate cancer?

Answer 7

Goserelin (zoladex)

Question 8

How does Goserelin (zoladex) work in Prostate cancer?

Answer 8

1. LH releasing hormone agonist
2. Reduces testosterone prod from testes

Question 9

What is a side fx of Goserelin (zoladex) used in prostate cancer?

Answer 9

Tumour flare (severe pain)

Question 10

How do you combat the Tumour flare side fx of Goserelin (zoladex) used in prostate cancer?

Answer 10

Co-prescribe: Cyproterone acetate
(anti-androgen medication)

Question 11

What can you also get alongside Horners syndrome in a Pancoast tumour?

Answer 11

Hand weakness + wasting

Question 12

What is the treatment of Pembertons sign (aka SVCO) in lung cancer?

Answer 12

Dexamethasone