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Anti-Cancer Drugs > PARP Inhibitors > Flashcards

PARP Inhibitors Flashcards

1
Q

Examples

A 
Olaparib
Dacarbazine
Temozolomide
Topotecan
Platinums
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2
Q

MoA

A

PARP1 protein
Inhibitor
Prevents repair of ssDNA damage
Causes ds breaks in DNA during DNA replication in actively replicating cancer cells lacking BRCA repair mechanisms

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3
Q

Indications

A

Breast + Ovarian cancer with BRCA mutations

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Anti-Cancer Drugs (8 decks)

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