Alkylating Agents Flashcards

1
Q

Examples

A

Cyclophosphamide
Isosfamide
Cisplatin
Carboplatin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

MoA

A

N7 atoms of guanine bases
Binds irreversibly to cross-link DNA during synthesis phase of cell-cycle
Prevent DNA splitting

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Indications

A

Solid + Haematological Tumours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

ADR

A
Hair loss
Mouth Ulcers
N+V+D
Local allergic reactions
BM suppression 
Infertility
Renal/Cardiac impairment
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Prescribing Advice

A

Cancer cells may develop resistance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly