Alkylating Agents Flashcards
1
Q
Examples
A
Cyclophosphamide
Isosfamide
Cisplatin
Carboplatin
2
Q
MoA
A
N7 atoms of guanine bases
Binds irreversibly to cross-link DNA during synthesis phase of cell-cycle
Prevent DNA splitting
3
Q
Indications
A
Solid + Haematological Tumours
4
Q
ADR
A
Hair loss Mouth Ulcers N+V+D Local allergic reactions BM suppression Infertility Renal/Cardiac impairment
5
Q
Prescribing Advice
A
Cancer cells may develop resistance