parkinsons drugs Flashcards
relieve symptoms of parkinsons disease
-crosses the BBB
levodopa/carbidopa
while taking levo/depo the patient suddenly develops a relapse of symptoms? this is called?
on-off syndrome: your health care provider can change your med regimen slightly to help dimish this effect.
what other meds will help with on-off phenomon
COMT and MOA
side effects of levo/dopa
N/V orthostatic hypo darkening of urine and sweat dyskinesisas symptoms of psychosis-hallucination, paranoriashol
how long does it take to get full effect of levo/depo
6 months for full response
should you take levo/dopa with food?
yes but avoid high protein foods (may cause GI probs)
dont take within 2 weeks of ____ when starting levo/dopa
MAOI antidepressants
what is the dopamine replacement drug?
levo/dopa
treats parkinsons disease and restless leg syndrome
pramipexole
what is worst when taking pramipexole?
sleep attacks & ortho-hypo & n/v
high protein meals does not interfer with?
pramipexole
if giving pramipexole for RLS, you should give
3 hrs before bedtime
what increases levels of pramipexole?
cimeidine
_____ and ___ increase the risk for adverse effects for pramipexole?
other CNS depressants & alcohol
treats major depression also
selegiline
avoid ___ while taking selegiline.
tyramine (aged cheese, red wine, choc,..etc)
what does a cholinergic crisis consist of?
salivation, lacrimation, urination, defecation (SLUD)
major side effect for selegiline?
hypertensive crisis & inomnia
diminsh cholinergic effect due to decreased dopamine
benztropine
side effects of bentropine?
n/v, atropine-like effects (dry mouth,blurred vision, mydriasis, urinary retention, constipation), anthistamine effects
