parkinsons drugs

Question 1

relieve symptoms of parkinsons disease

-crosses the BBB

Answer 1

levodopa/carbidopa

Question 2

while taking levo/depo the patient suddenly develops a relapse of symptoms? this is called?

Answer 2

on-off syndrome: your health care provider can change your med regimen slightly to help dimish this effect.

Question 3

what other meds will help with on-off phenomon

Answer 3

COMT and MOA

Question 4

side effects of levo/dopa

Answer 4

N/V
orthostatic hypo
darkening of urine and sweat
dyskinesisas
symptoms of psychosis-hallucination, paranoriashol

Question 5

how long does it take to get full effect of levo/depo

Answer 5

6 months for full response

Question 6

should you take levo/dopa with food?

Answer 6

yes but avoid high protein foods (may cause GI probs)

Question 7

dont take within 2 weeks of ____ when starting levo/dopa

Answer 7

MAOI antidepressants

Question 8

what is the dopamine replacement drug?

Answer 8

levo/dopa

Question 9

treats parkinsons disease and restless leg syndrome

Answer 9

pramipexole

Question 10

what is worst when taking pramipexole?

Answer 10

sleep attacks & ortho-hypo & n/v

Question 11

high protein meals does not interfer with?

Answer 11

pramipexole

Question 12

if giving pramipexole for RLS, you should give

Answer 12

3 hrs before bedtime

Question 13

what increases levels of pramipexole?

Answer 13

cimeidine

Question 14

_____ and ___ increase the risk for adverse effects for pramipexole?

Answer 14

other CNS depressants & alcohol

Question 15

treats major depression also

Answer 15

selegiline

Question 16

avoid ___ while taking selegiline.

Answer 16

tyramine (aged cheese, red wine, choc,..etc)

Question 17

what does a cholinergic crisis consist of?

Answer 17

salivation, lacrimation, urination, defecation (SLUD)

Question 18

major side effect for selegiline?

Answer 18

hypertensive crisis & inomnia

Question 19

diminsh cholinergic effect due to decreased dopamine

Answer 19

benztropine

Question 20

side effects of bentropine?

Answer 20

n/v, atropine-like effects (dry mouth,blurred vision, mydriasis, urinary retention, constipation), anthistamine effects