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Neuro > Parkinsons > Flashcards

Parkinsons Flashcards

1
Q

dopamine is broken down by what 2 enzymes

A

MAO and COM-T

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2
Q

which pathway predominates in parkinsons

A

indirect

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3
Q

L-DOPA

A

only effective for 3-5 years

99% excreted as DA in urine

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4
Q

L-DOPA AE

A

GI, CV arrhythmias, Orthostatic HypoTN

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5
Q

L-DOPA CX in

A

Vit B6
MAOI - hypertensive crisis
L-Amino Acids - compete for absorption
Peptic ulcer, cardiac dz, melanoma

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6
Q

L-DOPA/carbinodopa

A

L-AAD inhibitor
cant cross BBB
-prolongs halflife, reduces ADE

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7
Q

ADE of L-DOPA/carbinodopa

A

behavioral abnormalities

dyskinesisas

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8
Q

bromocriptine

A

Dopamine receptor agonist

D2-agonist, D1-partial agonist

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9
Q

apomorphine

A

Dopamine receptor agonist

D1/D2-agonist

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10
Q

Pramipexole

A

Dopamine receptor agonist
D2 selective agonist
free radical scavenger

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11
Q

Ropinirole

A

Dopamine receptor agonist
D2 selective
CYP1A2 metabolism

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12
Q

Amatadine

A

antiviral
-inc. DA synth and release
dec. DA uptake
short lived

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13
Q

ADE of Amantadine

A

restlessness, depression, agitation, irritability, insomnia, excitement, hallucinations, confucision
CX: hx. of seizures or HF

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14
Q

Selegiline

A

MAOI
retards breakdown of DA
metabolites (meth) inc. DA release

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15
Q

Rasagiline

A

MAOI

more potent than other.

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16
Q

ADE of MAO-B-I

A

L-DOPA ADE

CXind: merperidine, TCAs, SSRIs

17
Q

Entacapone

A

COMT inh.
protein bound
prefferred over other
only peripheral effects

18
Q

Tolcapone

A

COMT inh.
protein bound
central and peripheral effects
hepatic problems

19
Q

Benztropine

A 
antimuscarininc
- block cholinergic activation in striatum --> dec. gabaergic output of striatum
ADE
- CNS effects
- Anti-cholinergic effects
-CXind: prostatic hyperplasia
20
Q

Diphenhydramine

A 
antimuscarininc
- block cholinergic activation in striatum --> dec. gabaergic output of striatum
ADE
- CNS effects
- Anti-cholinergic effects
-CXind: prostatic hyperplasia
21
Q

Trihexyphenidyle

A 
antimuscarininc
- block cholinergic activation in striatum --> dec. gabaergic output of striatum
ADE
- CNS effects
- Anti-cholinergic effects
-CXind: prostatic hyperplasia
22
Q

Reserpine

A

DA depleting agent for HD chorea

23
Q

Tetraenazine

A

DA depleting agent for HD chorea

24
Q

Chlorpromazine

A

D2-R antagonist HD

25
Q

Haloperidol

A

D2-R antagonist HD

Neuro (17 decks)

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