Dementia/Dellerium

Question 1

Key features of dementia

Answer 1

insidious ognitive defect
irreversible
progressive without fluctuation
no disorder of alertness/attention

Question 2

Key features of delirium

Answer 2

acute disorder of confusion
reversible
acute with fluctuating course
alertness impaired
hyperactive autonomic function

Question 3

pathogenesis of Alz

Answer 3

accumulation of Abeta amyloid

Question 4

genetic basis of early onset AD

Answer 4

Ch. 21 - APP gene (downs association)
14 - presenilin 1
1 presenilin 2

Question 5

most important ris kfactor for late onset sporadic AD

Answer 5

Apo E4

Question 6

Microscopic path of AD (3)

Answer 6

beta amyloid plaques
neurofibrillary tangles (hyperphosphorylated tau)
decreased cerebral cortical neurons

Question 7

treatment of AD

Answer 7

increase AcH

anti Abeta Ab

Question 8

Dementia with lewy body main difference in presentation compared with parkinsons

Answer 8

dementia before Parkinsons signs

Question 9

Lewy bodies composed of

Answer 9

neurofilaments, alpha-synuclein,

Question 10

Picks disease, genetics

Answer 10

Ch. 17 - tau protein

Question 11

microscopic path of fronto-temporal dementia

Answer 11

pick bodies: ubiquitin and hyperphosphorylated TAU

Question 12

dementia following atherosclerotic abnormalities

Answer 12

vascular dementia