Pharm adrenergic and cholinergic

Question 1

alpha 1

Answer 1

Gq

Question 2

alpha 2

Answer 2

Gi

Question 3

beta

Answer 3

Gs

Question 4

most noradrenergic neurons

Answer 4

locus ceruleus - involved in regulating sleep, arousal, attention, vigilance

Question 5

Beta-adrenergic stimulation in amygdala can cause

Answer 5

PTSD

Question 6

what 2 receptor types are in the amygdala

Answer 6

alpha and beta 1

Question 7

Ach effects on N receptors

Answer 7

N receptor is a multimeric ion channel –> activation allows Na and Ca to depolarize cell

Question 8

Gq muscarinic receptors

Answer 8

M1, 3, 5

Question 9

Gi muscarinic receptors

Answer 9

M2, 4

Question 10

how are antipsychotic drugs chosen

Answer 10

least ADE

Question 11

Loss of accomodation, dry mouth, difficulty urinating, constipation caused by

Answer 11

Muscarinic cholinoceptor blocker

Question 12

Orthostatic hypotension, impotence, ejaculation failure caused by

Answer 12

alpha blocker

Question 13

parkinson’s syndrome, akathisia, dystonias

Answer 13

dopamine receptor blocker

Question 14

amenorrhea-galactorrhea, infertility

Answer 14

dopamine receptor blockade –> hyperprolactinemia

Question 15

3 MOAs of antidepressants

Answer 15

block reuptake of NE, seratonin, DA

Question 16

treat PTSD flashbacks (intrusions)

Answer 16

beta blocker

Question 17

treat PTSD insomnia

Answer 17

alpha blocker

Question 18

Paroxetine

Answer 18

SSRI labeled for PTSD

Question 19

Sertraline

Answer 19

SSRI labeled for PTSD

Question 20

2 strategies for treating parkinsons

Answer 20

• give dopamine

- anticholinergics

Question 21

3 drugs for Parkinsons

Answer 21

Benzotropine, diphenhydramine, trihexyphenidyl

Question 22

ADE for parkinson’s drugs

Answer 22

sedation, mental confusion, constipation, urinary retention, cycloplega

Question 23

H1 blocker central effects

Answer 23

sedation and confusion

Question 24

H1 blocker peripheral effects

Answer 24

opposite of dumbbells