Movement Disorders Flashcards
Hypokinetic Disorders (3)
Parkinson’s
Progressive Supranuclear Palsy
Multiple system atrophy
Micropath found in PD
lewy bodies
- fried-egg appearance
- alpha synuclein
Onset and 4 cardinal features
ASYMETRIC ONSET - rest tremor rigidity bradykinesia postural instability LATER
other characteristic features of parkinsonss
masked face
stooped posture
hypokinetic dysarthria (slurred speech)
micrgraphia
micrographia
parkinsons
masked face
PD
shuffling gait with decreased arm swinging
PD
hypokinetic dysarthria
PD
micrographia
PD
REM sleep behavior disorder
PD
Neurofibrillary tangles of phospho-tau proteins
Progressive Supranuclear Palsy
initial manifestation: decreased ability for voluntary down-gaze
Progressive Supranuclear Palsy
supranuclear gaze palsy
Progressive Supranuclear Palsy
Key differences in features of PD and PSP
PSP:
tremor negative
balance problems are early findings
symmetric rigidity
3 key features of Multiple system atrophy
extrapyramidal dysfunction - parkinsonism
autonomic dysfunction
cerebellar dysfunciton
inspiratory stridor
Multiple system atrophy
involuntary signing/raynauds
Multiple system atrophy
differences between Multiple system atrophy and PD
postural instability early
no tremor
earlier and more severe ANS findings
NO dimentia
3 Hyperkinetic disorders
huntingtons
tourettes
primary idiopathic dystonia
chromosome of HD gene
4
sustained repetitive twisting that leads to abnormal postures
primary idiopathic dystonia
gene of primary idiopathic dystonia and inheritance
Torsin A
AD inheritance
Ch. 9
low penetrance
dromedary gait
primary idiopathic dystonia
primary generalized dystonia begins
in lower extremity
primary focal dystonia begins
above waist
microscopic halmark of wilsons disease
Opalski cell
most common neuro feature of wilsons
kinetic/intention tremor
