Movement Disorders Flashcards
Hypokinetic Disorders (3)
Parkinson’s
Progressive Supranuclear Palsy
Multiple system atrophy
Micropath found in PD
lewy bodies
- fried-egg appearance
- alpha synuclein
Onset and 4 cardinal features
ASYMETRIC ONSET - rest tremor rigidity bradykinesia postural instability LATER
other characteristic features of parkinsonss
masked face
stooped posture
hypokinetic dysarthria (slurred speech)
micrgraphia
micrographia
parkinsons
masked face
PD
shuffling gait with decreased arm swinging
PD
hypokinetic dysarthria
PD
micrographia
PD
REM sleep behavior disorder
PD
Neurofibrillary tangles of phospho-tau proteins
Progressive Supranuclear Palsy
initial manifestation: decreased ability for voluntary down-gaze
Progressive Supranuclear Palsy
supranuclear gaze palsy
Progressive Supranuclear Palsy
Key differences in features of PD and PSP
PSP:
tremor negative
balance problems are early findings
symmetric rigidity
3 key features of Multiple system atrophy
extrapyramidal dysfunction - parkinsonism
autonomic dysfunction
cerebellar dysfunciton