Parkinsons Flashcards
Parkinson’s disease
Progressive, degenerative disorder of basil ganglia function
basal ganglia
Function with cerebellum to make smooth coordinated movements
Substantia nigra
Within basal ganglia
Cells that produce dopamine
primary parkinsonism
Genetic, sporadic
Idiopathic
Secondary parkinsonism
Acquired-infection, trauma, drug induced, intoxication
risk factors
Over 40, peaks at 70
Male
Genetics
Anxiety/depression
Head trauma
Hysterectomy – low estrogen
Coffee consumption – protective
acetyl choline
Excitatory neurotransmitter
Stimulate muscle movement
dopamine
Inhibitory transmitter
Function- message transmission
Controls movement in balance, helps muscles work smoothly
Controllable and without unwanted movement
Patho of parkinsonism
Destruction of substantia nigra in basal ganglia
Decrease dopamine
Imbalance between dopamine an ACH
Relative excess ACH
Loss of control movement in balance
s/sx parkinsonism
Brady kinesia
Cogwheel rigidity
Resting tremor
Shuffling gait
Mask like impression
Gait instability
are the signs of Parkinson’s disease, slow or rapid?
Slow, gradual and progressive
triad of Parkinson disease
Tremor
Rigidity
Brady kinesia
Tremor
Often first sign
handwriting affected
More prominent at rest
Aggravated by stress, or increased concentration
essential tremor
Results from faulty neural impulses
Occurs in motion with motor function
No other signs of Parkinson’s
Parkinson’s tremors
Decrease dopamine
Occurs at rest
Improved with movement
Presents with other symptoms
