Myasthenia Gravis Flashcards
myasthenia gravis
Autoimmune disorder
Fluctuating weakness of certain muscle groups
course of disease
Short term remission
Stabilization
Severe, progression
risk factors
10 to 65 years old
Females
patho
anti-ACH antibodies attack ACH receptors
Decreased ACH receptor sites at neuromuscular junction
Prevents ACH molecules from attaching to and stimulating muscle contraction
s/sx
fluctuating weakness in skeletal muscles
Muscles – eyes, face
Difficulty speaking, breathing
T/F myasthenia gravis has an insidious onset
True
what occurs after rest with myasthenia gravis?
Strength comes back
myasthenia gravis crisis
Acute exacerbation of muscle weakness
Not enough ACH
Triggers of MG crisis
infection
Surgery
Emotional distress
Pregnancy, Menses
Inadequate pharm therapy
major complications of crisis
Breathing muscle weakness
Respiratory distress
pharm
immunosuppressants
Steroids
Cholinesterase inhibitors
are cholinesterase inhibitors a cure or symptom relief
Symptom relief
Cholinergics
Increased G.I. motility, diarrhea
Increase secretions
Bladder urgency
Bradycardia
Bronchial constriction
Miosis – construction
Anti-cholinergics
Decreased motility, constipation
Dry mouth
Urinary retention
Tachycardia
Bronchodilation
Mydriasis – dilation
cholinergic crisis
Extreme muscle weakness/paralysis
Smooth muscle overexcited ability
Too much ACH or nystigmine