Myasthenia Gravis Flashcards

1
Q

myasthenia gravis

A

Autoimmune disorder

Fluctuating weakness of certain muscle groups

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2
Q

course of disease

A

Short term remission
Stabilization
Severe, progression

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3
Q

risk factors

A

10 to 65 years old
Females

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4
Q

patho

A

anti-ACH antibodies attack ACH receptors

Decreased ACH receptor sites at neuromuscular junction

Prevents ACH molecules from attaching to and stimulating muscle contraction

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5
Q

s/sx

A

fluctuating weakness in skeletal muscles

Muscles – eyes, face
Difficulty speaking, breathing

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6
Q

T/F myasthenia gravis has an insidious onset

A

True

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7
Q

what occurs after rest with myasthenia gravis?

A

Strength comes back

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8
Q

myasthenia gravis crisis

A

Acute exacerbation of muscle weakness

Not enough ACH

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9
Q

Triggers of MG crisis

A

infection
Surgery
Emotional distress
Pregnancy, Menses
Inadequate pharm therapy

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10
Q

major complications of crisis

A

Breathing muscle weakness
Respiratory distress

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11
Q

pharm

A

immunosuppressants
Steroids
Cholinesterase inhibitors

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12
Q

are cholinesterase inhibitors a cure or symptom relief

A

Symptom relief

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13
Q

Cholinergics

A

Increased G.I. motility, diarrhea
Increase secretions
Bladder urgency
Bradycardia
Bronchial constriction
Miosis – construction

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14
Q

Anti-cholinergics

A

Decreased motility, constipation
Dry mouth
Urinary retention
Tachycardia
Bronchodilation
Mydriasis – dilation

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15
Q

cholinergic crisis

A

Extreme muscle weakness/paralysis
Smooth muscle overexcited ability
Too much ACH or nystigmine

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16
Q

Treatment for cholinergic crisis

A

mechanical ventilation
Antidote – atropine

17
Q

What to do to distinguish between MG and cholinergic crisis

A

give edrophonium

If symptoms improve – MS crisis
If symptoms worsen – cholinergic crisis