Parkinson's disease

Question 1

Name the 4 dopamine pathways in the brain.

Answer 1

Nigrostriatal pathway, mesolithic pathway, mesocortiyal pathway & tuberoinfundibular pathway.

Question 2

Which drug is primarily used to treat Parkinson’s disease.

Answer 2

L-DOPA + carbidopa

Question 3

What does Cabidopa do?

Answer 3

Blocks DOPA carboxylase in the periphery.

Question 4

Name a parkinson’s drug that blocks MAO-B.

Answer 4

Selegiline

Question 5

Name the mode of action of Entacapone.

Answer 5

It inhibits COMT.

Question 6

Name the mode of action of Bromocriptine.

Answer 6

It is an agonist of the dopamine receptors.

Question 7

Name the mode of action of Domperidon.

Answer 7

It is a dopamine antagonist in the periphery.

Question 8

What is Anticholinergica used for?

Answer 8

It helps with tremors, inhibits muscarine receptors.

Question 9

Name the early side effects of L-DOPA.

Answer 9

Nausea, orthostatic hypertension, psychological symptoms, tachycardia.

Question 10

Name the late side effect go L-DOPA.

Answer 10

Hyperkinesia.

Question 11

Name the side effects of COMT inhibitors.

Answer 11

GI-tract problems.