Antidepressants

Question 1

Name the 3 mechanisms of action that antidepressant drugs have.

Answer 1

Inhibits re-uptake of monoamines, decreases degradation of monamines, monoamine-receptor antagonists –> increase release of monoamines.

Question 2

Name the mechanism of TCA drugs.

Answer 2

Inhibits re-uptake of noradrenaline and serotonin. Increased synaptic levels of NA and 5-HT.

Question 3

Give two examples of TCA drugs.

Answer 3

Imipramine and clomipramine.

Question 4

Name the major groups of drug used to treat depression.

Answer 4

TCA, Selective serotonin-re-uptake inhibitors, Selective noradrenalin re-uptake inhibitors, selective serotonin-and-noradrenaline re-uptake inhibitors, monoamine oxidase inhibitors & presynaptic alpha-2-receptor antagonists.

Question 5

Name 4 commonly used SSRIs.

Answer 5

Citalopram - cipramil
Escitalopram - cipralex
Sertraline - zoloft
Fluoxetine - Fontex, prozac

Question 6

Name one NRI.

Answer 6

Reboxetine - Edronax

Question 7

Name 2 SNRIs.

Answer 7

Venlafaxine - Efexor

Duloxetine - cymbalta

Question 8

Name a MAO inhibitor.

Answer 8

Moclobemide - aurorix

Question 9

Name two presynaptic alpha-2-receptor antagonists.

Answer 9

Miaserin - Miaserin, Tolvon

Mirtazapin - Remeron

Question 10

Name 2 antipsychotic drug.

Answer 10

Quetiapine - Seroquel

Olazapine - Zyprexan

Question 11

Name the mechanism of action of Ketamine.

Answer 11

Increased glutamate release - AMPA receptor activation - activation of mTOR system - morphological changes of synapses - restored neuronal network.

Question 12

Which is the first drug of choice in treating bipolar disease?

Answer 12

Lithium.

Question 13

Which two antipsychotic drug are used to treat bipolar disease?

Answer 13

Quetiapine - noradrenaline reuptake-inhibitor.

Olazapine.

Question 14

Name 3 mood-stabilising drugs used to treat bipolar disease.

Answer 14

Carbamazepine, valproate and lamotrigine.