Anti-inflammatory & immunosuppressant drugs Flashcards
1
Q
Name the 3 main effects of NSAID.
A
Antipyretic, analgesic & anti-anti-inflmmatory.
2
Q
What is Ciklosporin?
A
Potent immunosuppressive.
3
Q
Where in the body is COX-1 and 2 located?
A
COX-1 - most cells/tissues
COX -2- inflammatory cells, endothelial cells, kidney, CNS
4
Q
What is the function of COX-1 and 2?
A
COX-1 - Housekeeping, modulate vascular response, regulate gastric secretion.
COX-2 - inflammation.
5
Q
How are prostanoids synthezised?
A
COX oxidises AA in two steps producing PGG2 and PGH2. Different enzymes convert PGH2 to different prostaglandins.
6
Q
Which is the most common COXIB?
A
Rofecoxib
7
Q
Which cox enzyme is present in the GI-tract.
A
COX 1, inhibition leads to peptic ulcer and GI bleeding.
