Parkinson's disease Flashcards
1
Q
Which drug must be given with L-dopa?
A
Carbidopa
2
Q
What does carbidopa do?
A
Inhibits peripheral DOPA decarboxylase, thus preventing peripheral degradation of L-dopa
3
Q
Which enzymes break down dopamine?
A
COMT and MAO
4
Q
Which enzyme converts L-dopamine => dopamine
A
Dopa decarboxylase
5
Q
What is the action of entcapone in the treatment of Parkinson’s disease?
A
It inhibits COMT, preventing peripheral breakdown of L-dopa
6
Q
What is the action of cabergoline and bromocriptine in the treatment of Parkinson’s disease?
A
Dopamine agonists
7
Q
What is the action of selegiline in the treatment of Parkinson’s disease?
A
Inhibits MAO-B, thus prevents breakdown of central dopamine
