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Pharm Exam 4 > Parkinson's/Alzheimer's > Flashcards

Parkinson's/Alzheimer's Flashcards

0
Q

Carbidopa

A

Parkinson’s

Inhibits dopa carboxylase, lessens peripheral effects of l-dopa when given in combo.

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1
Q

Levodopa

A

Parkinson’s tx

Do not give w/ MAOIs (HTN)

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2
Q

Carbidopa/Levodopa

A

Parkinson’s
Do not give w/ MAOIs (HTN), more side effects w/ Vit B6
If psychosis do not give haloperidol (give D4 blockers)
bad in GI ulcers, melanoma

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3
Q

Selegiline

A

Parkinson’s
MAOI-B inhibitor, slows down disease (less free radicals)
Serotonin syndrome w/ TCAs, SSRIs, Meperidone

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4
Q

Rasagiline

A

Parkinson’s

Selective MAOI-B, no tyramine restrictions, less insomnia

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5
Q

Bromocriptine

A

Parkinson’s - DA agonist
+l-dopa when on-off start
Ergot derivative - erythomelalgia!

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6
Q

Pergolide

A

Parkinson’s

Ergot derivative, not on the market anymore

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7
Q

Ropinirole

A

Parkinson’s & restless leg syndrome
DA agonist, less on-off
Sudden sleep

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8
Q

Pramipexole

A

Parkinson’s
DA agonist, less likely to cause on-off
Sudden-sleep

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9
Q

Amantadine

A

Parkinson’s tx
Antiviral- flu prophylaxis
Inc synth and release of DA

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10
Q

Tolcapone

A

Parkinson’s
Inhibits COMT (less DA breakdown slows disease)
LIVER PD
dyskinesias, psychosis, sudden sleep, hypotension

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11
Q

Entacapone

A

Parkinson’s
Inhibits COMT (less DA breakdown, slows progression)
RHABDOMYOLYSIS
dyskinesias, psychosis, sudden sleep, hypotension

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12
Q

Benztropine

A

Parkinson’s

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13
Q

Biperiden

A

Parkinson’s

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14
Q

Donepezil

A

Alzheimer’s
AChE Inhibitor, slows prog, works better w/ memantine
N/V/D

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15
Q

Rivastigmine

A

Alzheimer’s
AChE Inhibitor, slows progression, works better w/ Memantine
N/V/D

16
Q

Galantamine

A

Alzheimer’s
AChE inhibitor, slows progression, works better w/ Memantine
N/V/D

17
Q

Memantine

A

Alzheimer’s
Blocks NMDA receptor, works better w/ AChEIs
Kidney excretion, inc side effects of l-dopa
DI: Meperidine, Dextromethorphan

Pharm Exam 4 (9 decks)

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