CNS muscle relaxants

Question 0

Tizanidine

Answer 0

a2 receptor analogue
Inhibits pain transmission - acute and chronic
Sedating

Question 1

Baclofen

Answer 1

GABAb receptor agonist
Dec spasticity
Intrathecal administration, tolerance

Question 2

Cyclobenzaprine

Answer 2

Sedating muscle relaxant
Antimuscarinic: Acute mm spasms tx
Sedation, confusion (not good for the elderly)
HALLUCINATIONS

Question 3

Caprisoprodol

Answer 3

Sedating muscle relaxant, alters perception of pain
Met to meprobamate (barbiturate-like)- drug of abuse
Induces hepatic enzymes, not very effective

Question 4

Sedating muscle relaxants

Answer 4

Chlorzoxazone, Metaxalone, Methocarbamol, Orphenadrine, Chlorphenesin

Question 5

Metaxalone

Answer 5

Spinal cord sedative

Question 6

Methocarbamol

Answer 6

Spinal cord sedative

Question 7

Orphenadrine

Answer 7

Spinal cord sedative

Question 8

Dantrolene

Answer 8

For emergencies - neuroleptic malignant syndrome, malignant hyperthermia
Inhibits excitation-contraction (skeletal>cardiac, smooth)

Question 9

Botulinum Toxin

Answer 9

Inhibits ACh release

Inject locally, for muscle spasms after stroke, eye strabismus