Antipsychotics

Question 0

Thioridazine

Answer 0

Phenothiazine   Anti-psychotic
Blocks D2, a1, histamine
Low potency (D2)- dec EPS
inc sedation/hypotension
Retinal deposits

Question 1

Chlorpromazine

Answer 1

Phenothiazine   Anti-psychotic
Blocks D2, a1, histamine
Low D2 potency -dec EPS
inc sedation/hypotension
Jaundice, corneal deposits

Question 2

Fluphenazine

Answer 2

Phenothiazine Anti-psychotic
High potency D2 block - inc EPS
Low anticholinergic - dec side effects

Question 3

Prochlorperazine

Answer 3

Phenothiazine Anti-psychotic

Anti-emetic

Question 4

Trifluoperazine

Answer 4

Phenothiazine Anti-psychotic

High potency D2 block- inc EPS, dec sedation/hypotension

Question 5

Haloperidol

Answer 5

Anti-psychotic - Acute mania tx
D2 block - inc EPS
no anticholinergic activity

Question 6

Thiothixene

Answer 6

Anti-psychotic

similar to phenothiazines

Question 7

Pimozide

Answer 7

Anti-psychotic Tourette’s
D2 block + some anticholinergic activity
inc EPS, prolongs QT

Question 8

Molindone

Answer 8

Anti-psychotic - rarely used

High EPS

Question 9

Loxapine

Answer 9

Anti-psychotic - rarely used

Lowers seizure threshold

Question 10

Olanzapine

Answer 10

Atypical anti-psychotic Bipolar disorder
Blocks D2, D4, 5HT2a, some anticholinergic
Rare EPS, tardive dyskinesia
No agranulocytosis
Weight gain, hyperglycemia, T2DM

Question 11

Risperidone

Answer 11

Atypical anti-psychotic Schizophrenia
Bocks D2, 5HT2a, a1
Rare EPS (high doses), tardive dyskinesia
Long acting, dose x2weeks, better complinace
Prolongs QT, inc prolactin, inc mortality in Alzheimer’s

Question 12

Ziprasidone

Answer 12

Atypical anti-psychotic
Acute mania - Tourette’s
Prolongs QT, inc seizures

Question 13

Clozapine

Answer 13

Atypical anti-psychotic
Blocks D4 (+sx) & 5HT2a (-sx)- blocks muscarinic, histamine, a1
Rare tardive dyskinesia, EPS
Agranulocytosis, seizure, weight gain - last choice drug

Question 14

Quetiapine

Answer 14

Atypical anti-psychotic - Schizophrenia - Bipolar
Blocks D4, 5HT2a, a1, histamine (like clozapine less side effects)
No inc prolactin, low EPS, no agranulocytosis
Weight gain, sedation

Question 15

Iloperidone

Answer 15

Atypical anti-psychotic
Block D2, 5HT2a, no antimuscarinics
Prolongs QT when met is impaired

Question 16

Paliperidone

Answer 16

Atypical anti-psychotic

Active metabolite/extended release of Risperidone

Question 17

Lurasidone

Answer 17

Atypical anti-psychotic Depression + bipolar
Block D2, 5HT, partial agonist at 5HT1a
Agranulocytosis

Question 18

Asenaprine

Answer 18

Atypical anti-psychotic - PTSD (nightmares)
Blocks 5HT, histamine, a1 (not D2 or muscarinic)
Not much weight gain
Sedation/hypotension

Question 19

Aripiprazole

Answer 19

Atypical anti-psychotic Depression Bipolar
Partial agonist D2, 5HT1a “Dopamine stabilizer”
Blocks 5HT2a, a1, histamine
No wt gain, no EPS
Hyperglycemia, T2DM, esophageal motility pb

Question 20

Neuroleptic Malignant syndrome

Answer 20

Occurs on anti-psychotics, discontinue meds, administer Dantrolene + Diazepam for seizures.

Question 21

Antipsychotics with a1 blockade

Answer 21

Phenothiazines (Chlorpromazine, thioridazine...)
Haloperidol
Olanzapine, Clozapine
Quetiapine
Iloperidone, Lurasidone
=postural hypotension

Question 22

Antipsychotics w/ muscarinic, histamine blockade

Answer 22

Phenothiazides (Chlorpromazine, thioridazine...)
Clozapine
Olanzapine
Quetiapine
Apriprazole
=sedation, dry mouth, constipation