Alcohol withdrawal

Question 0

Disulfiram

Answer 0

Inhibits aldehyde dehydrogenase
No effect by itself
Long duration (3-4d)
Dangerous (acetaldehyde build-up)

Question 1

Ethanol

Answer 1

Tx for ethylene glycol or methanol poisoning.

Question 2

Phenytoin

Answer 2

Acute alcohol tx
Anticonvulsant - prolongs Na inact,
Partial and Gen tonic-clonic (not absence)
P450 inducer, Hirsutism, gingival hyperplasia, Pregnancy Cat. D, SJS

Question 3

Naltrexone

Answer 3

Opoid receptor antagonist (pain killers don’t work on it)
Inhibits effect of alcohol on reward pathways (chronic tx)
Dec relapse, dec cravings
CI: LIVER DAMAGE

Question 4

Nalmefene

Answer 4

Opoid receptor antagonist - Chronic alcohol withdrawal

Longer duration and less liver damage than Naltrexone

Question 5

Acamprosate

Answer 5

GABA analogue: restores balance b/w GABA & Glutamate
(chronic alcohol tx)
Dec relapse, dec intake
No liver damage, no abuse potential

Question 6

Topiramate

Answer 6

Anticonvulsant -Dec cravings (chronic alcohol tx)
Mood stabilizer - monotx for bipolar
Anti-convulsant- inc Na inac: partial, tonic-clonic, multiple, infantile spasm, absence seizures
Wt loss, migraine prophylaxis, Preg Cat C

Question 7

Ondansetron

Answer 7

Anti-emetic

Dec relapse in early-onset alcoholics (chronic tx)

Question 8

Gabapentin

Answer 8

Anti-convulsant -Dec likelihood of drinking x4 (chronic alcohol tx)
Mood stabilizer
For neuropathic pain
CI in pregancy

Question 9

Fomezipol

Answer 9

Inhibits alcohol dehydrogenase

Tx for ethylene glycol or methanol poisoning