Anti-convulsants

Question 0

Levetiracetam

Answer 0

Anti-convulsant
Binds SV2A
Partial, myoclonic, and gen tonic-clonic seizures

Question 1

Primidone

Answer 1

Anti-convulsant - partial and gen tonic clonic seizures
GABA agonist
SJS, Preg Cat. D, metabolized like phenobarbital

Question 2

Lamotrigine

Answer 2

Mood stabilizer (effective) - No wt gain
Anti-convulsant - prolongs Na+ ch inactivation
Partial, myoclonic and absence in children, gen tonic-clonic seizures
SJS (important-use in children), Preg Cat. C
T1/2 doubled by valproic acid

Question 3

Vigabatrin

Answer 3

Anti-convulsant - GABA agonist (dec its met)

Visual field problems/retinal damage

Question 4

Tiagabine

Answer 4

Anti-convulsant - GABA agonist
Adjunct for partial seizures
SJS, preg cat. C

Question 5

Ethosuximide

Answer 5

Anti-convulsant - dec Ca++ current
DOC for absence seizures
Preg Cat. D, SJS (important)
Valproic acid inc T1/2

Question 6

Partial and Generalized Tonic-clonic seizures tx

Answer 6

Phenytoin, Carbamazepine, Gabapentin, Levetiracetam, Lamotrigine, Topiramate, Tigabine, Phenobarbital, Valproic acid

Question 8

Absence seizures tx

Answer 8

Ethosuximide
Lamotrigine
Clonazepam
Valproic acid

Question 9

Myoclonic seizures

Answer 9

Levetiracetam

Valproic acid

Question 10

Atonic seizures tx

Answer 10

Valproic acid

Lamotrigine

Question 11

Infantile spasm tx

Answer 11

corticosteroids

Topiramate

Question 12

Status epilepticus tx

Answer 12

Diazepam (IV), Lorazepam (IV)
Phenytoin
Phenobarbital

Question 13

Steven-Johnson Syndrome - Hypersensitivity

Answer 13

Life threatening in: Phenytoin, , Lamotrigine, Ethosuximide, Valproic acid.
Others: Carbamazepine, Phenobarbital, Primidone, Topiramate, Tiagabine.