Antidepressants Flashcards
Desipramine
TCA- 2ary amine (less sedation/antichol, more NE)
Imipramine
TCA -3ary amine (inc sedation, inc 5HT, inc anticholinergic)
For enuresis
Amitriptyline
TCA- 3ary amine (more sedation)
Nortriptyline
TCA - 2ary amine
Least cardiac effects
Timipramine
TCA- 3ary amine
Doxepine
TCA- 3ary amine
Clomipramine
TCA - 3ary amine
For OCD
Protriptyline
TCA- 2ary amine
Phenelzine
MAOI
Tranylcypromine
MAOI
Fluoxetine
SSRI - Prozac
LONG T1/2 (4wks to reach ss, 5wks to get rid off)
Inhibits CYP2D6- interactions w/ TCA, warfarin, phenytoin/carbamazepine, bb, opoids, tamoxifen, tramadol (seizures)
Fluvoxamine
SSRI
Paroxetine
SSRI + OCD and social anxiety
Inhibits CYP2D6 - DI w/ TCA, warfarin, phenytoin/carbamazepine, BB, opoids.
Some sedation, GI side effects. NOT safe in pregnancy
Sertaline
SSRI
Similar to Fluoxetine, less DI, shorter T1/2
Citalopram
SSRI
-Fewer side effects and DI
useful in hot flashes