Antidepressants Flashcards

0
Q

Desipramine

A

TCA- 2ary amine (less sedation/antichol, more NE)

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1
Q

Imipramine

A

TCA -3ary amine (inc sedation, inc 5HT, inc anticholinergic)

For enuresis

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2
Q

Amitriptyline

A

TCA- 3ary amine (more sedation)

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3
Q

Nortriptyline

A

TCA - 2ary amine

Least cardiac effects

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4
Q

Timipramine

A

TCA- 3ary amine

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5
Q

Doxepine

A

TCA- 3ary amine

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6
Q

Clomipramine

A

TCA - 3ary amine

For OCD

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7
Q

Protriptyline

A

TCA- 2ary amine

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8
Q

Phenelzine

A

MAOI

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9
Q

Tranylcypromine

A

MAOI

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10
Q

Fluoxetine

A

SSRI - Prozac
LONG T1/2 (4wks to reach ss, 5wks to get rid off)
Inhibits CYP2D6- interactions w/ TCA, warfarin, phenytoin/carbamazepine, bb, opoids, tamoxifen, tramadol (seizures)

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11
Q

Fluvoxamine

A

SSRI

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12
Q

Paroxetine

A

SSRI + OCD and social anxiety
Inhibits CYP2D6 - DI w/ TCA, warfarin, phenytoin/carbamazepine, BB, opoids.
Some sedation, GI side effects. NOT safe in pregnancy

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13
Q

Sertaline

A

SSRI

Similar to Fluoxetine, less DI, shorter T1/2

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14
Q

Citalopram

A

SSRI
-Fewer side effects and DI
useful in hot flashes

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15
Q

Escitalopram

A

SSRI - fastest onset
Fewer side effects and DI
Useful in hot flashes

16
Q

Venlafaxine

A

SNRI - for chronic pain
Inhibits reuptake of 5HT & NE
Inc BP

17
Q

Desvenlafaxine

A

SNRI

18
Q

Duloxetine

A

SNRI - depression associated pain

Inc liver enzymes, some CYP2D6 inhibition

19
Q

Milnacipram

A

SNRI - fibromyalgia

Induces liver enzymes

20
Q

Levomilnacipram

A

SNRI

21
Q

Bupropion

A

Anti-depressant - inhibits DA reuptake
Smoking cessation (ext release), alcoholism, night eating, ADHD
FEWER SEXUAL SIDE EFFECTS, can give anxiety
CI: seizures or head trauma

22
Q

Mirtazapine

A

Anti-depressant - blocks presynaptic a2, blocks 5HT2a & 5HT3
no cardiac toxicity
sedation (antihistamine), wt gain

23
Q

Atomoxetine

A

Anti-depressant - blocks NE reuptake
ADHD med for <6yo
CI w/ vasopressors (epi, ne) and MAOIs
GI pd, hepatotoxicity

25
Q

Maprotiline

A

Anti-depressant - blocks NE reuptake

cardiac effects, seizures

27
Q

Amoxapine

A

Anti-depressant - blocks NE (&5HT) reuptake, blocks DA receptor
Some antipsychotic effect, sedation

27
Q

Traxodone

A

Anti-depressant (not very good) - partial agonist at 5HT1a, blocks 5HT2a
For pain management and insomnia
sedation, PRIAPISM

27
Q

St Johns Wort

A

Anti-depressant - effective for mild depression

Photosensitivity, don’t combine w/ other antidepressants, harder to get out of anesthesia

28
Q

HTN crisis

A

When combine MAOIs w/ tyramine (wine/cheese) or sympathomimetics (cold meds) or Buspirone.
Tx w/ phentolamine (a-blocker)

29
Q

Serotonin syndrome

A

Hyperpyrexia, convulsions, twitches, delirium
If combine MAOIs w/ TCAs, SSRIs, Meperedine, or Dextromethorphan
If combine SSRIs w/ MAOIs, St John’s wort, amphetamines.
Tx w/ benzos

30
Q

SSRIs

A

DOC for depression, panic disorder, OCD
Also used in social anx, bulimia, PMDD, alcoholism, premature ejac
No memory impairement- can use in children/adolescent/elderly
Side effects: GI, photosensitivity, wt gain (chronic)

31
Q

Selegeline

A

MAOI, selective for MAO-B (breaks down DA)

32
Q

Vortioxetine

A

SSRIs + agonist at 5HT1a- anxiolytic

33
Q

Viladozone

A

SSRI + agonist at 5HT1a - anxiolytic