Parkinson's

Question 1

What neurotransmitter reduction causes Parkinson’s?

Answer 1

Dopamine

Question 2

Where in the brain is the substantia nigra located?

Answer 2

Basal ganglia

Question 3

What is the classic triad of symptoms in Parkinson’s?

Answer 3

Resting tremor

Cogwheel rigidity

Bradykinesia (slower and smaller movements)

Question 4

What are 3 examples of bradykinesia?

Answer 4

Handwriting gets smaller and smaller

Shuffling gait

Difficulty initiating movement

Difficulty turning around when standing

Reduced facial expressions

Question 5

What type of dementia is associated with Parkinson’s?

Answer 5

Lewy body

Question 6

Treatment options in Parkinson’s and an example of each (4)

Answer 6

Levodopa

Catechol O methyltransferase inhibitors e.g entacapone

Dopamine agonists e.g pergolide and bromocryptine

Monoamine oxidase inhibitors e.g salegiline