Lambert Eaton Syndrome

Question 1

Lambert Eaton syndrome presents similarly to what other condition?

Answer 1

Myasthenia gravis

Question 2

What cancer is Lambert Eaton syndrome associated with?

Answer 2

Small cell lung cancer (SCLC)

Question 3

In Lambert Eaton syndrome, autoantibodies are produced against voltage gated ___ channels in SCLC cells, which can also target the same channels in the neuromuscular junction

Answer 3

Calcium

Question 4

Why is less acetylcholine released into the synapse of the neuromuscular junction in Lambert Eaton syndrome?

Answer 4

Calcium channels are responsible for assisting in the release of acetylcholine into the neuromuscular junction. The channels are destroyed meaning less acetylcholine.

Question 5

The blank blank muscles are typically affected in Lambert Eaton syndrome

Answer 5

Proximal leg

Question 6

What symptoms does Lambert Eaton syndrome present with that are the same as Myasthenia gravis? (4)

Answer 6

Diplopia

Ptosis

Dysphagia

Slurred speech

Question 7

What is a post tetanic presentation in Lambert Eaton syndrome

Answer 7

Muscle reflexes will be normal for a short time after the muscle involved has been contracted for a period

Question 8

What is the primary medication given in Lambert Eaton syndrome and what is the class of drug?

Answer 8

Amifampridine (potassium channel antagonist)