Guillian Barre Syndrome

Question 1

What 3 organisms can cause Guillian Barre syndrome?

Answer 1

Campylobacter Jejuni

CMV

EBV

Question 2

Define molecular mimicry in the context of Guillian Barre syndrome

Answer 2

The B cells create antibodies against a pathogen’s antigens. These antibodies also bind to the proteins on nerve cells, either on the myelin sheath or the axon itself, causing damage

Question 3

What is the characteristic presentation of Guillian Barre syndrome? (4)

Answer 3

Symmetrical ascending weakness starting at feet

Reduced reflexes

Periphery loss of sensation or neuropathic pain

May progress to cranial nerves causing facial weakness in late disease

Question 4

Symptoms of Guillian Barre syndrome usually start within how many weeks post infection?

Answer 4

Within 4

Question 5

In Guilty Barre syndrome, symptoms peak within __ to __ weeks followed by a recovery period that can last months to years

Answer 5

2 to 4

Question 6

What criteria is used to diagnose Guillian Barre syndrome?

Answer 6

Brighton

Question 7

What investigations can be done to support a diagnosis of Guillian Barre syndrome? (2)

Answer 7

Nerve conduction studies

Lumbar puncture showing raised protein with a normal cell and glucose count

Question 8

Management of Guillian Barre syndrome? (3)

Answer 8

Supportive

IV immunoglobulins or plasma exchange

VTE prophylaxis