Parasympatholytic Drugs (2)

Question 1

Atropine

Answer 1

Brand Name: Atropine

Classification: Anticholinergic

Action: Antagonizes acetylcholine receptors

Indications: Treat Symptomatic Bradycardias especially those arising in the Atria

Contraindications: None in emergency settings

Dose: 0.5mg repeat every 3-5 mins (max 3.0mg)

Routes: IV or IO

Adverse Effects: blurred vision, dilated pupils, dry mouth, tachycardia, drowsiness

Other: Organophosphate poisonings may require a significantly higher dose

Question 2

Ipratropium

Answer 2

Brand Name: Atrovent

Classification: Muscarinic anticholinergic (parasympathetic stimulation)

Action: Selectively blocks muscarinic receptors inhibiting parasympathetic stimulation

Indications: Bronchospasms associated with obstructive lung disease

Contraindications: Hypersensitivity

Dose: 500 mcg

Routes: Inhaled

Adverse Effects: Blurred Vision, Dry Mouth, Dilated Pupils, Cough, Confusion

Other: Typically administered with a beta agonist (although not as frequently)