Opiod Antagonists (2) ; Opioid Agonist-Antagonists (2) Flashcards
Naloxone
Brand Name: Narcan
Classification: Opiate Antagonist
Action: Opioid antagonist without opiate agonist properties (it has not activity when given in the absence of an opiate agonist
Indications: Partial reversal of opiate drug effects, Opiate overdose
Contraindications: Hypersensitivity
Dose: 0.4-2.0 mg
Routes: IV, IO, SQ, IN, Nebulizer
Adverse Effects: Fever, Chills, Nausea, Vomiting, Diarrhea, Opiate withdrawal
Other: Administer enough to reverse respiratory depression and avoid full narcotic withdrawal syndrome
Nalmefene
Brand Name: Revex
Classification: Opiate antagonist
Action: Opioid Antagonist without opiate agonist properties (if no activity when given in the absence of an opiate agonist)
Indications: Partial reversal of opiate drug effects, Opiate overdose
Contraindications: Hypersensitivity
Dose: 0.4-2.0 mg
Routes: IV, IM, SQ, IO, nebulizer
Adverse Effects: Fever, Chills, Nausea, Vomiting, Diarrhea, Opiate withdrawal
Other: Duration of effect much longer than naloxone
Nalbuphine
Brand Name: Nubain
Classification: Opiate agonist-antagonist
Action: Analgesia and sedation through binding to opiate receptors. It also has some opiate receptor antagonistic properties
Indications: Moderate-Severe Pain
Contraindications: Hypersensitivity, Opiate dependence, Respiratory depression
Dose: 10-20 mg
Routes: IV, IO, SQ
Adverse Effects: Sedation, Dizziness, Nausea, Vomiting, Opiate withdrawal
Other: Use with caution in patients with liver and renal disease
Butorphanol
Brand Name: Stadol
Classification: Opiate agonist-antagonist (class IV)
Action: Analgesia and sedation through binding with opiate receptors, it also has some opiate receptor antagonistic properties
Indications: Moderate-Severe pain
Contraindications: Hypersensitivity, opiate dependence, respiratory depression
Dose: 1-4mg
Routes: IV, IM, SQ, IO, IN
Adverse: Sedation, dizziness, nausea, vomiting, opiate withdrawal
Other: use with caution in pts with liver and renal disease
