Antipsychotic Drugs (3)

Question 1

Haloperidol

Answer 1

Brand Name: Haldol

Classification: Butyrophenone

Action: Blocks dopamine receptors associated with mood and behavior

Indications: Psychosis

Contraindications: Hypotension and Hypersensitivity

Dose: 2-10 mg

Routes: IM, PO

Adverse Effects: Extrapyramidal reactions, insomnia, restlessness, dry mouth, hypotension, tachycardia

Other: Hypotension more common in patients taking antihypertensive

Question 2

Chlorpromazine

Answer 2

Brand Name: Thorazine

Classification: Phenothiazine

Action: Blocks dopamine receptors associated with mood and behavior

Indications: Psychosis, intractable hiccups

Contraindications: hypotension and hypersensitivity

Dose: 25-50mg

Routes: IM, PO

Adverse: Extrapyramidal reactions, insomnia, restlessness, dry mouth, hypotension, tachycardia

Other: hypotension more common in pts taking antihypertensive

Question 3

Ziprasidone

Answer 3

Brand Name: Geodon

Classification: Unclassified antipsychotic

Action: inhibits uptake of serotonin and dopamine

Indications: psychosis, Tourette’s syndrome

Contraindications: Hypersensitivity

Dose: 50-100mcg

Routes: IM, PO

Adverse: Extrapyramidal reactions, insomnia, restlessness, dry mouth, hypotension, tachycardia

Other: Carbamazepine (Tegretol) can decrease ziprasidone levels