Papovaviridae

Question 1

This is the prototype polyomavirus that is tumorigenic in hamsters and are well-studied as models of tumor-causing viruses

Answer 1

SV40 (simian virus)

Question 2

T/F Papillomaviridae family is a very small virus family

Answer 2

F

Question 3

How many genera do Papillomaviridae has?

Answer 3

16 genera

Question 4

What are the 5 genera of Papillomaviridae that infect humans?

Answer 4

Alpha-
Beta-
Gamma-
Mupa-
Nupapapillomavirus

Question 5

T/F: Polyomaviridae family has a single genus designated polyomavirus

Answer 5

T

Question 6

Fill in the following for Papillomaviridae:
Capsid symmetry:
Nucleic acid core:
Prescence of envelope (yes or none):

Answer 6

Icosahedral
Circular dsDNA
None

Question 7

Which classification of HPV contains a group associated with cervical CA? (Cutaneous or mucosal)

Answer 7

mucosal HPV

Question 8

How many structural proteins do papillomaviruses have?

Answer 8

2

Question 9

How many Early and Late genes are there for HPV DNA?

Answer 9

1-8 Early (E1-E8)
2 Late (L1-L2)

Question 10

Papillomaviruses are highly tropic on which cells?

Answer 10

epithelial cells

Question 11

HPV viral nucleic acid can be found in which epidermal cells?

Answer 11

basal stem cells

Question 12

HPV late gene expression (capsid proteins) is restricted to which epidermal cells?

Answer 12

uppermost layer of differentiated cells

Question 13

T/F: Viral replicative cycle of HPV is independent of specific factors

Answer 13

F: Papillomaviruses are dependent on specific factor that are present in sequential differentiated states of epithelial cells

Question 14

Transmission of HPV

Answer 14

close contact

Question 15

Which cells of epidermal layer is released in transmission of HPV?

Answer 15

basal cell layer

Question 16

HPV 1, 2, 3, 4:
Which cause/s plantar warts?

Answer 16

HPV 1

Question 17

HPV 1, 2, 3, 4:
Which cause/s cutaneous lesions with low oncogenic potential?

Answer 17

HPV 3

Question 18

HPV 1, 2, 3, 4:
Which cause/s benign common skin warts?

Answer 18

HPV 2, 4

Question 19

HPV type that causes Hand warts of butchers

Answer 19

HPV 7

Question 20

HPV type that causes Epidermodysplasia verruciformis include the following except:
A. 5
B. 8
C. 13
D. 14

Answer 20

C.

Question 21

HPV with high correlation with cervical CA

Answer 21

HPV 16 and 18

Question 22

HPV type causing Condylomata acuminatum

Answer 22

HPV 6 and 11

Question 23

2 HPV early proteins that complexes with Rb and p53

Answer 23

E6 and E7

Question 24

HPV Early protein that stabilizes EGFR enhancing proliferation

Answer 24

E5

Question 25

HPV Early protein that inactivates p105 retinoblastoma gene product

Answer 25

E7

Question 26

Peak incidence of HPV infections occurs in which age groups?

Answer 26

adolescents and young children <25 yo

Question 27

Head and neck SCC are linked to which HPV type

Answer 27

HPV 16

Question 28

HPV types that are the most common cause of benign epithelial tumor of the larynx

Answer 28

HPV 6 and 11

Question 29

T/F: anogenital warts caused by HPV 6 and 11 rarely become malignant

Answer 29

T

Question 30

HPV types causing recurrent respiratory papillomatosis

Answer 30

HPV 6 and 11

Question 31

Cytologic changes seen in pap smears with cervical dysplasia caused by HPV

Answer 31

Koilocytic cells

Question 32

1st neoplastic changes noted on light microscopy for cervical neoplasia or CA due to HPV

Answer 32

Dysplasia

Question 33

Histologic appearance in microscopy for HPV

Answer 33

hyperplasia of prickle cells and hyperkeratorisis

Question 34

T/F: Cell cultures are good for HPV diagnostics

Answer 34

F

Question 35

T/F: HPV antibodies are often used for diagnosis

Answer 35

F

Question 36

The mainstay of HPV treatment of laryngeal papilloma

Answer 36

surgery

Question 37

Approved immunomodulatory treatment for Condylomata acuminatum

Answer 37

Alpha interferon

Question 38

Toll-like receptor ligand that stimulate innate response to attack HPV infections

Answer 38

Imiquimod (Aldara)

Question 39

Topical treatment for Extensive genital warts

Answer 39

Topical Idoxuridine

Question 40

Used for topical and intralesional treatment of warts by selectively killing the HPV-infected cells by inducing apoptosis and inhibiting DNA polymerase

Answer 40

Cidofovir

Question 41

Capsid protein used for HPV vaccine

Answer 41

L1