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MICROBIOLOGY MED2 > Papovaviridae > Flashcards

Papovaviridae Flashcards

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Biology 101 flashcards
1
Q

This is the prototype polyomavirus that is tumorigenic in hamsters and are well-studied as models of tumor-causing viruses

A

SV40 (simian virus)

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2
Q

T/F Papillomaviridae family is a very small virus family

A

F

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3
Q

How many genera do Papillomaviridae has?

A

16 genera

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4
Q

What are the 5 genera of Papillomaviridae that infect humans?

A

Alpha-
Beta-
Gamma-
Mupa-
Nupapapillomavirus

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5
Q

T/F: Polyomaviridae family has a single genus designated polyomavirus

A

T

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6
Q

Fill in the following for Papillomaviridae:
Capsid symmetry:
Nucleic acid core:
Prescence of envelope (yes or none):

A

Icosahedral
Circular dsDNA
None

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7
Q

Which classification of HPV contains a group associated with cervical CA? (Cutaneous or mucosal)

A

mucosal HPV

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8
Q

How many structural proteins do papillomaviruses have?

A

2

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9
Q

How many Early and Late genes are there for HPV DNA?

A

1-8 Early (E1-E8)
2 Late (L1-L2)

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10
Q

Papillomaviruses are highly tropic on which cells?

A

epithelial cells

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11
Q

HPV viral nucleic acid can be found in which epidermal cells?

A

basal stem cells

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12
Q

HPV late gene expression (capsid proteins) is restricted to which epidermal cells?

A

uppermost layer of differentiated cells

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13
Q

T/F: Viral replicative cycle of HPV is independent of specific factors

A

F: Papillomaviruses are dependent on specific factor that are present in sequential differentiated states of epithelial cells

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14
Q

Transmission of HPV

A

close contact

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15
Q

Which cells of epidermal layer is released in transmission of HPV?

A

basal cell layer

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16
Q

HPV 1, 2, 3, 4:
Which cause/s plantar warts?

A

HPV 1

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17
Q

HPV 1, 2, 3, 4:
Which cause/s cutaneous lesions with low oncogenic potential?

A

HPV 3

18
Q

HPV 1, 2, 3, 4:
Which cause/s benign common skin warts?

A

HPV 2, 4

19
Q

HPV type that causes Hand warts of butchers

A

HPV 7

20
Q

HPV type that causes Epidermodysplasia verruciformis include the following except:
A. 5
B. 8
C. 13
D. 14

A

C.

21
Q

HPV with high correlation with cervical CA

A

HPV 16 and 18

22
Q

HPV type causing Condylomata acuminatum

A

HPV 6 and 11

23
Q

2 HPV early proteins that complexes with Rb and p53

A

E6 and E7

24
Q

HPV Early protein that stabilizes EGFR enhancing proliferation

A

E5

25
Q

HPV Early protein that inactivates p105 retinoblastoma gene product

A

E7

26
Q

Peak incidence of HPV infections occurs in which age groups?

A

adolescents and young children <25 yo

27
Q

Head and neck SCC are linked to which HPV type

A

HPV 16

28
Q

HPV types that are the most common cause of benign epithelial tumor of the larynx

A

HPV 6 and 11

29
Q

T/F: anogenital warts caused by HPV 6 and 11 rarely become malignant

A

T

30
Q

HPV types causing recurrent respiratory papillomatosis

A

HPV 6 and 11

31
Q

Cytologic changes seen in pap smears with cervical dysplasia caused by HPV

A

Koilocytic cells

32
Q

1st neoplastic changes noted on light microscopy for cervical neoplasia or CA due to HPV

A

Dysplasia

33
Q

Histologic appearance in microscopy for HPV

A

hyperplasia of prickle cells and hyperkeratorisis

34
Q

T/F: Cell cultures are good for HPV diagnostics

A

F

35
Q

T/F: HPV antibodies are often used for diagnosis

A

F

36
Q

The mainstay of HPV treatment of laryngeal papilloma

A

surgery

37
Q

Approved immunomodulatory treatment for Condylomata acuminatum

A

Alpha interferon

38
Q

Toll-like receptor ligand that stimulate innate response to attack HPV infections

A

Imiquimod (Aldara)

39
Q

Topical treatment for Extensive genital warts

A

Topical Idoxuridine

40
Q

Used for topical and intralesional treatment of warts by selectively killing the HPV-infected cells by inducing apoptosis and inhibiting DNA polymerase

A

Cidofovir

41
Q

Capsid protein used for HPV vaccine

A

L1

MICROBIOLOGY MED2 (9 decks)

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