Finals: Integrative

Question 1

Dengue diagnostic test/s for acute phase (<5 days after fever onset)

Answer 1

DENV specimen PCR
Nonstructural protein 1 (NS1) assays

Question 2

CBC lab test is requested for dengue around which day after fever onset?

Answer 2

4th or 5th day
when WBC decreases (neutropenia), platelet decreases while hematocrit increases

Question 3

What dengue test is requested at 5 days or more after the onset of fever?

Answer 3

IgM anti-DENV enzyme-linked immunosorbent assay (MAC ELISA)

Question 4

Major class of immunoglobulin found in the serum

Answer 4

IgG

Question 5

Longest half-life among the Ig classes

Answer 5

IgG

Question 6

Most efficiet immunogloculin in agglutination, complement fixation, and other antugen-antibidy reactions as it is secreted as a pentamer

Answer 6

IgM

Question 7

Major Ig responsible for mucosal immunity

Answer 7

IgA

Question 8

In mucous secretions, IgA is a dimer and referred to as:

Answer 8

secretory IgA

Question 9

Ig that has an additional constant region (CH4)

Answer 9

IgE

Question 10

This is the major surface bound Ig on mature B lymphocytes that have not yet encountered an antigen

Answer 10

IgD

Question 11

These 2 Immunoglobulins are the only isotype that can be expressed together by the same cell

Answer 11

IgD and IgM

Question 12

Common name for dermatophytosis

Answer 12

Ring worm (tineas)

Question 13

Dermatophyte that only infects the skin and nails

Answer 13

Epidermophyton

Question 14

Dermatophyte that only infects the skin and hair

Answer 14

Microsporum

Question 15

True or false: Dermatophytes are resistant to cycloheximide

Answer 15

True

Question 15

True or false: Dermatophytes are resistant to cycloheximide

Answer 15

True

Question 16

The several dermatophytic species that are capable of sexual reproduction produce ____________ and belong to the teleomorphic genus __________.

Answer 16

ascospores
Arthroderma

Question 17

If a fragment of chromosomal DNA has been incorporated into the plasmid, it is designated as an:

Answer 17

F’ plasmid

Question 18

If F plasmid sequence is integrated into the bacterial chromosome, the cell is designated an:

Answer 18

Hfr (High frequency recombination) cell

Question 19

DOC for Sporotrichosis

Answer 19

Itraconazole

Question 20

Guarnieri bodies areintracytoplasmic finding in infections caused by:

Answer 20

Variola or small pox

Question 21

Cowdry type A in Tzanck smear is seen in which infection?

Answer 21

Herpes Simplex Virus [2?]

Question 22

A dense central, ‘‘owl’s eye,” basophilic inctranuclear inclusion body is the histologic hallmark of which infection?

Answer 22

Cytomegalovirus

Question 23

Which genera of herpesvirdae are classified under betaherpes?

Answer 23

Cytomegalovirus and Roseolovirus

Question 24

Latent infection of virus from Rhadinovirus genus is found in:

Answer 24

Lymphoid tissue Rhadinovirus is HHV 8 (Kaposi's sarcoma-associated herpesvirus)

Question 25

The genus Lymphocryptovirus is classified under which subfamily of Herpesviridae?

Answer 25

Gammaherpes (with Rhadinovirus)

Question 26

Latent infections of HHV 5 are found in:

Answer 26

glands and kidneys HHV 5 is CMV under the betaherpes subfamily

Question 27

This cytopathological finding distinguish HSV & VZV from Coxsackievirus

Answer 27

Multinucleated Giant cells (syncytia formation)

Question 28

T/F: Serology is useful in the diagnosis of HSV

Answer 28

F: Serology is not useful for HSV diagnosis except for epidemiology

Question 29

Drug of Choice for HSV

Answer 29

Acyclovir

Question 30

The most important criterion for the recognition of Staphylococcus species

Answer 30

Coagulase production

Question 31

Test used to identify Streptococcus pneumonia (susceptible) as this reveals "No zone of inhibition" around the disk among other viridans group strep

Answer 31

Optochin test

Question 32

Tetanospasmin blocks the release of which inhibitory transmitters?

Answer 32

glycine and GABA

Question 33

Type of conidia seen in aspergilloma

Answer 33

Phialoconidia

Question 34

Aspergillus species that is the most common cause of invasive and chronic aspergillosis

Answer 34

A. fumigatus

Question 35

Aspergillus species that causes invasive infection primarily in patients with chronic granulomatous disease

Answer 35

A. nidulans

Question 36

Opportunistic fungi that peoduce aerial hyphae that bear conidial structures and long conidiophores with terminal vesicles

Answer 36

Aspergillus

Question 37

What are the primary risk factors for invasive aspergillosis?

Answer 37

Profound neutropenia and glucocorticoid use

Question 38

A mycetoma caused by a bacteria

Answer 38

Actinomycetoma

Question 39

A definitive pathologic diagnosis of rabies can be based on the finding of ________________ in the brain or the spinal cord. They are sharply demarcated, more or less spherical, and 2–10 µm in diameter, and they have a distinctive internal structure with basophilic granules in an eosinophilic matrix.

Answer 39

Negri bodies

Question 40

Sugars in TSI

Answer 40

Glucose Lactose Sucrose

Question 41

This E. coli will have negative (clear colonies) on sorbitol MacConkey agar (sorbitol is used instead of lactose)

Answer 41

STEC O157:H7

Question 42

Selective media for vibrio

Answer 42

Thiosulfate-citrate-bile-sucrose agar