Cytokines and Complement

Question 1

These proteins serve to mediate and regulate immune and inflammatory responses

Answer 1

cytokines

Question 2

Which of the following is NOT true of a cytokine?
A. Acts on many different cell types
B. Has multiple different effects on the same target
C. Actions are often redundant
D. Produced during the activation phase of natural and specific immunity

Answer 2

D. should be: during effector phase

Question 3

Which of the following cytokines is not produced by TH1 cells?
A. IL-2
B. TNF-β
C. IL-6
D. IL-3
E. IFN-γ

Answer 3

C. IL-6 is produced by dendritic cells and macrophages for innate immunity and TH2 cells for adaptive immunity

Question 4

Which of the following is not produced by TH2 cells?
A. IL-23
B. IL-13
C. IL-9
D. IL-3
E. IL-10

Answer 4

A. IL-23 is produced by dendritic cells and macrophages of the innate immunity

Question 5

What are the cytokines produced by TH17 cells?

Answer 5

IL-17, IL-21, IL-22, TNF-α, GM-CSF

Question 6

Which of the following is not produced by Dendritic and Macrophages for innate immunity?
A. IL-1
B. IL-12
C. IL-18
D. TGF-β
E. chemokines

Answer 6

D. TGF-β is produced by Treg cells along with IL-10

Question 7

Which acute phase cytokine is involved in vascular permeability, tissue remodeling, metabolism, maintenance of macrophage activation and cachexia?

Answer 7

TNF-α

Question 8

Which acute phase cytokine is responsible for lymphocyte activation?

Answer 8

IL-6

Question 9

Which cytokine promotes TH1 response and activates NK cells?

Answer 9

IL-12

Question 10

Which cytokine promotes TH17 response from memory cells?

Answer 10

IL-23

Question 11

Which cytokine has an antiviral effect and promotes CD8 T-cell response?

Answer 11

Type 1 IFN

Question 12

Which cytokine activates macrophages, dendritic, T and B cells?

Answer 12

IFN-γ

Question 13

Which of the following is not an anti-inflammatory cytokine?
A. TGF-β
B. IL-10
C. IFN-β
D. IL-11
E. NOTA

Answer 13

E. NOTA

Question 14

aka Leukocyte IFN

Answer 14

IFN-α

Question 15

aka Fibroblast IFN

Answer 15

IFN-β

Question 16

The principal mediator (cytokine) of host response to gram-negative bacteria

Answer 16

Tumor Necrosis Factor
- major cellular source: LPS-activated mononuclear phagocyte

Question 17

Which of the following does not occur with Moderate concentration of TNF?
A. Pyrogen release
B. Coagulation activation
C. Metabolic alterations of cachexia
D. Intravascular thrombosis
E. Bone Marrow suppression

Answer 17

D. Intravascular thrombosis which leads to decreased perfusion occurs in Massive quantities of TNF produced

Question 18

Cytokine that causes fever with TNF, induces synthesis of acute plasma proteins by the liver and initiate metabolic wasting

Answer 18

IL-1

Question 19

Which of the following is a growth factor for activated B-cells?
A. TGF-β
B. IL-6
C. IL-1
C. TNF
D. GM-CSF

Answer 19

IL-6

Question 20

Which of the following is a chemokine that predominantly acts on NEUTROPHILS as mediators of acute inflammation?
A. IL-2
B. IL-4
C. IL-6
D. IL-8

Answer 20

D. IL-8