Pandemics Flashcards

1
Q

Learning Objectives

A
  • Understanding:
  • The nature of pandemics
  • Causes of pandemics
  • Methods of controlling pandemics
  • Gaining awareness of The historical and current impact of pandemics on human populations
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2
Q

What’s the difference between an epidemic and a pandemic?

A
  • Epidemic: The occurrence in a defined region of cases of a disease in the human population in excess of normal expected numbers
  • Pandemic: An epidemic occurring worldwide, or over a very wide area, crossing international boundaries and usually affecting a large number of people
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3
Q

Why do pandemics occur?

A
  • Emergence / introduction of a new disease capable of infecting humans
  • Or the Re-emergence of a disease not seen in human populations for many years Leading to a serious illness that is readily transmissible & sustainable in the human population
  • Mechanisms to allow easy and sustainable spread in human population
  • Wholly susceptible population
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4
Q

How is a Pandemic declared?

A
  • WHO uses the conditions on the previous slide to decide whether to declare a pandemic.
  • Declaration of a pandemic has largely been replaced by a declaration of a Public Health Emergency of International Concern – PHEIC
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5
Q

Why are pandemics potentially damaging to societies in terms of health impacts?

A
  • High morbidity: Difficult to treat patients adequately! Medical services/facilities overwhelmed. Staff exhaustion/morale, Shortages of medicines etc, Shortages of PPE, Shortages of beds. Rehabilitation of cases. Mental health
  • High mortality: May be difficult to dispose of the dead, Legal issues, Social/personal impact
  • Long term health concerns: Failure/delay in treating other health problems, Increased morbidity/mortality from untreated conditions. Long term impact of infection on individuals. Impact on health care staff
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6
Q

Why are pandemics potentially damaging to societies in terms of social and economic impacts? (PART 1)

A

Impact on the workforce:
- Immediate – reduction in available workforce, lockdowns, lost income.
- Long term – loss of jobs, loss of skills, lost income.
- Impact on physical and mental health

Impact on infrastructure
- Transport (food, fuel distribution)
- Power
- Water/waste
- Security/law & order/justice services

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7
Q

Why are pandemics potentially damaging to societies in terms of social and economic impacts? (PART 2)

A

Economic damage
- Damage to national/international trade
- Damage to travel/transport industries/tourism
- Business & store closures/job losses/furloughs/unemployment

Social impact
- Impact of control measures (e.g. Lockdowns)
- Damage to education
- Damage to social structures
- Fake news/conspiracies/blaming external groups
- Social unrest
- [Long term social change]

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8
Q

How do we minimise the immediate effects of a pandemic?

A
  • Try to reduce the number of cases
  • Delay the peak number of cases
  • Reduce the height peak number of infections
  • Spreas the cases over a longer period of time
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9
Q

How do we control a pandemic?

A

Requires:
- A very high level of national & international collaboration in all relevant fields
- Active & effective epidemiological, surveillance & public health systems
- High grade medical care & facilities
- Collaborative research: understanding organisms
- Social responsibility by national populations: Preventing social breakdown
- Good and unimpreded flows of accurate information within & between nations neutralising rumours
- Political will

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10
Q

What are some health and public health interventions that humans can take?

A
  • Epidemiological investigation & surveillance
  • Detection, isolation & treatment of cases & quarantine of contacts: effective surveillance system, active & effective test & trace system
  • Social distancing: Minimize disease transmission, morbidity & mortality by reducing contact between individuals
  • Reduce demands on medical/health-care services: Encourage home nursing, Minimise use of medical facilities by those who can be cared for at home. Delay treatment for other non urgent conditions
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11
Q

What is the difference between quarantine & isolation?

A
  • These are control & preventive measures. They are a legacy of the many pandemics over the centuries.
  • Quarantine: restrict the movement of well persons who may have been exposed to a disease, to prevent the spread of the disease to the healthy
  • Isolation: separate persons ill with a communicable disease from those who are healthy
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12
Q

Provide a brief history of how quarantine was used in the legacy of the Black Death

A
  • From a Venetian dialect form of the Italian quaranta giorni, - “40 days”
  • In 1377, the Rector of the port of Ragusa, (Dubrovnik in Croatia) officially imposed the “trentina” a 30-day isolation period for ships & people.
  • Detention of forty days (quarantina) instituted by the city of Marseille in 1383 & became the standard period of quarantine
  • 1896 – quarantine replaced by port health inspection
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13
Q

What is the R0 / Rt(Re) concepts?

A
  • R0 (Basic reproduction number), is the expected number of cases directly generated by one case in a population where all individuals are susceptible to infection
    • Rt or Re (Effective reproduction number) is the number of cases generated in the current state of a population, which does not have to be the uninfected state.
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14
Q

What happens if these values are below 1?

A
  • The disease will decline. This can be achieved by:
  • Increasing Herd immunity: Allow infection to run unchecked/with some limits, Vaccination
  • Physical intervention: Respiratory system protection, Hygiene measures, Lockdowns, Test & trace, Isolation/quarantine of cases/contacts
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15
Q

What do masks do?

A

Masks do 2 things:
- Source protection: Reduced virus transmission from the wearer
- Wearer protection: Reduced rate of infection of the wearer
- WHO advice: Wear a fabric mask unless you’re in a particular risk group

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16
Q

When should you wear a medical/surgical mask?

A
  • Are over 60
  • Have underlying medical conditions
  • Are feeling unwell
  • Are looking after an ill family member
17
Q

Describe Face shields as defensive measures against infections?

A
  • Plastic face shields
  • Alone these are not a fully effective defence against COVID-19 infection
  • Good at arresting most large droplets
  • Lighter particles can enter the open areas around the visor
  • Shield + mask is a good defence
18
Q

Describe social distancing as defensive measures against infections?

A
  • Most expelled particles travel less than 2 metres
  • Smaller particles and aerosols can travel much further
  • Distancing will reduce risk, not eliminate it & needs to be combined with other measures (e.g. masks).
19
Q

Describe handwashing as defensive measures against infections?

A
  • Regular handwashing is an essential part of basic hygiene
  • Handwashing removes/kills pathogens preventing transmission from hands to mucous membranes
  • Soap/detergents kill COVID-19
  • Hand sanitisers containing at least 60% alcohol are also effective
20
Q

Describe ventilation as a defensive measure against pandemics

A
  • Research shows that being in a room with fresh air can
    reduce the risk of infection from particles by over 70%
  • Kitchen or bathroom extractor fans, used correctly and
    regularly, help to remove infected particles
  • Air conditioners (especially those using fresh air & not
    recirculation) present little risk of spreading the virus.
21
Q

How can pandemics be transmitted through surfaces?

A
  • Lab tests showed that some pathogens can survive: quite well on hard surfaces (several days), less well on surfaces like cardboard & paper (24 hours)
  • These tests were artificial
  • Much current advice on surface cleaning is based on these early reports.
  • *NB. Evidence suggests that items such as surfaces & packaging are not an important route of infection with COVID-19. This does not mean that surface cleaning should be abandoned
22
Q

Do preventative measures work?

A
  • Non-pharmaceutical
  • Appear to be effective against many respiratory infections
  • During Covid, flu & other RTI numbers were very
    low
  • Better vaccination?
  • Fewer samples taken?
  • Laboratories redirected?
23
Q

List the historical effects of pandemics

A
  • Antonine plague: decline of the Roman empire
  • Plague of Justinian: prevented spread of Byzantine Empire into Italy, changed the course of European history
  • Smallpox: Major factor in the Spanish conquest of the Aztec & Incan civilizations
  • Black death: Created a series of religious, social & economic upheavals, profoundly affected European history
24
Q

Describe what happened during the Black Death

A
  • A massive outbreak of plague ravaged Europe throughout
    the 14th Century
  • Estimated killed 75 - 200 million people in the 14th
    century alone
  • 45 - 60% of the population of Europe wiped out
  • Reduced world’s population from ca. 450 million to 350 -
    375 million by 1400
  • Took 150 years for Europe’s population to recover
25
Q

What was the origin of the Black Death?

A
  • Originated in China 1331, Halfed their popn to 60 million
  • Entered Constantinople in 1347
  • Reportedly first introduced to Europe at Caffa in the Crimea in 1347
  • Genoese carried the plague by ship to Sicily & southern
    Europe, whence it spread north
  • Several existing conditions such as war, famine, & weather
    contributed to the severity of the Black Death.
26
Q

What affects did The Black Death have on people around the world?

A
  • Profoundly affected the way people thought about their world
  • The Church: Declined as people became disillusioned
  • Feudal system declined
  • Literature: Chronicled by famous writers, philosophers &
    rulers such as Boccaccio & Petrarch.
  • Art: Several themes persisted especially dealing
    with the frailty of life & the triumph of death
  • Flagellants: Religious movement seeking redemption
    through mortification of the flesh
  • Attacks on minorities: Jews, lepers, foreigners
27
Q

Describe Influenza

A
  • Enveloped RNA viruses (Orthomyxoviridae)
  • RNA viruses have very high mutation rates – correlated with enhanced virulence & evolvability*
  • Influenza viruses - 4 strains, 3 can affect humans
28
Q

List the 4 types of influenza viruses and their features

A
  • Influenza A: wild aquatic birds are natural hosts! the most virulent & causes the most severe disease, the cause of pandemics/panzootics
  • Influenza B: less common than influenza A, almost exclusively infects humans
  • Influenza C: infects humans, dogs & pigs, least common type in humans, causes mild disease in
    children
  • Influenza D: pigs & cattle
29
Q

Describe the features of influenza in general

A
  • Seasonal epidemics: Can cause excess deaths (>25,000 in UK in some years)
  • Occasional severe pandemics
  • Spreads easily
  • Many symptoms similar to Covid-19 infection
    – People infective before symptoms appear
    – Spread by: droplet inhalation, via contaminated hands
  • Transmission risk reduced if people cover their mouth & nose when coughing, & wash their hands regularly
30
Q

Describe the epidemiology of influenza

A
  • Incubation period 2-4 days
  • All age groups affected
  • Health care workers at high risk due to increased exposure & risk further spread to vulnerable individuals
31
Q

Who are the People at risk of severe disease or complications are?

A
  • pregnant women
  • children < 59 months
  • the elderly (>65Y)
  • individuals with chronic medical conditions
  • individuals with immunosuppressive conditions (e.g. HIV/AIDS, chemotherapy or steroids, malignancy)
  • health care workers