Pancreatic Cancer Flashcards

1
Q

what type of jaundice indicates pancreatic cancer?

A

Painless obstructive jaundice

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

anatomically where are most pancreatic cancers located in the pancreas?

A

head of pancreas.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

most pancreatic cancers are what type of cancer histologically?

A

adenocarcinomas

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

define adenocarcinomas?

A

Cancer that begins in glandular (secretory) cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what is Courvoisier’s Law?

A

a palpable gallbladder with painless obstructive jaundice is unlikely to be due to gallstones

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

mutations in which genes are risk factors for pancreatic cancer?
-2

A

BRCA2 gene

KRAS gene mutation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

which endocrine disorders are risk factors for pancreatic cancer?
-2

A

Multiple endocrine neoplasia

Diabetes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

risk factors for pancreatic cancer?

-8

A
Old
Smoker
Diabetes
Chronic pancreatitis
Hereditary non-polyposis colorectal carcinoma
Multiple endocrine neoplasia
BRCA2 gene 
KRAS gene mutation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

how many pancreatic cancer pts have a KRAS gene mutation? (%)

A

90%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

symptoms of pancreatic cancer?

-6

A

pale stools, dark urine, pruritus
Weight loss
Steatorrhoea
Diabetes syptoms - polyuria, thirsty

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

define pruritus?

A

itching

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what type of jaundice indicates pancreatic cancer?

and symptoms caused by this?
-4

A

Painless obstructive jaundice = pale stools, dark urine, pruritus, yellow skin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Losing exocrine function in pancreatic cancer causes what symptoms?
-2

A

steatorrhoea + weight loss

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Losing endocrine function in pancreatic cancer causes what symptom?
-1

A

diabetes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

1st Ix?

A

US

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

IX of Choice?

A

CT

17
Q

results on LFTs?

A

↑↑ALP ↑GGT ↑Bilirubin

18
Q

Tumour maker for pancreatic cancer?

A

CA 19-9

19
Q

what is the definitive treatment for pancreatic cancer?
- has 2 names

how many people eligible for this procedure?

A

Whipple’s resection aka pancreaticoduodenectomy +chemotherapy after surgery

20% actually suitable for surgery

20
Q

treatment method for most people with pancreatic cancer?

A

palliative for most people

21
Q

what procedure can relieves symptoms, but is not a cure.

A

ERCP