Barrett's Oesophagus Flashcards
from which tissue type does adenocarcinoma originate?
glandular
normal histology of oesophagus?
Squamous epithelium
Barret’s histology of oesophagus?
Columnar epithelium
pathophysiology of Barret’s Oesophagus ?
repeat reflux, acid causes metaplasia
which cancer type has an increased risk with Barret’s Oesophagus?
how big is this increase?
adenocarcinoma
↑75x
risk factors?
-4
GORD
Fat
Male (7:1)
Smoking
strongest risk factor?
GORD
how does obesity increase Barret’s Oesophagus risk?
-3
extra fat pushes on stomach causing reflux.
as stomach distends it pulls down LES weakening it so more reflux.
extra oestrogen from fat causes reflux.
Gold. S Ix?
Endoscopy
1st line Mx?
PPI +
endoscopy surveillance
why do you do endoscopy surveillanc?
check cancer
The histology of the oesophagus changes in Barrett’s.
what is the term given for the changing of one histological tissue type to another?
metaplasia
what do you give to treat GORD?
PPI
what is the main dietary advice?
-1
no fatty foods
if dysplasia is seen on endoscopy what is the 1st line treatment?
Endoscopic mucosal resection
