IBS Flashcards

1
Q

what does IBS stand for?

A

Irritable Bowel Syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

how long must you have symptoms of IBS before we can say it is IBS?

A

6 months

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what makes abdo pain better in IBS?

- this is a requirement for it to be diagnosed as IBS

A

pain relieved by defecating

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

which age group is most at risk?

A

20-30

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

which gender is most at risk?

A

female

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what happens to prevalence with age?

A

decreases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what foods/drinks can increase risk?

-give 4

A

alcohol
caffeine
spicy
fatty foods

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

which drug group commonly causes IBS?

A

antibiotics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what are the risk factors for IBS?

-7

A
GI infection 
GI inflammation 
diet 
psychosocial factors 
drugs
younger age group 
female
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

how many people have their symptoms triggered by foods?

% wise

A

90%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what psychosocial factors can increase risk?

A

stress
anxiety
depression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what are the differentials?

- give 4

A

crohn’s
coeliac
cancer
UC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

complications of IBS?

-2

A

depression, anxiety

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

does acupuncture help IBS?

A

no

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

pt has typical IBS Hx, but also has rectal bleeding.

what should be a differential now?
-2

A

cancer

UC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

pt has typical IBS Hx, but also has weight loss.

what should be a differential now?
-3

A

crohn’s
coeliac
cancer

17
Q

pt has typical IBS Hx, but these symptoms have started now at 68 years of age.

what should be a differential now?

A

cancer

18
Q

pt has typical IBS Hx, but also has a FHx of cancer.

what should be a differential now?

A

cancer

19
Q

what are the ABC symptoms of IBS?

A

Abdo pain
Bloating
Change in bowel habit (diarrhoea/constipation)

20
Q

how long you do need the ABC symptoms of IBS before we can consider a diagnosis?

A

6 months

21
Q

can you get mucus in stool in IBS?

A

yes

22
Q

can you get blood in stool in IBS?

A

no

must be a different condition then

23
Q

what type of diagnosis is IBS?

A

diagnosis of exclusion

24
Q

what blood tests did NICE say you can use to exclude differentials?
-4

A

FBC
ESR, CRP
Coeliac serology

25
Q

pt has just been diagnosed with IBS.

diarrhoea is main symptom.

what OTC can they try to help this?
how long for?

A

probiotics

4 weeks

26
Q

pt has just been diagnosed with IBS.

constipation is main symptom.

what lifestyle change can they try to help this?

A

high fibre diet

27
Q

is exercise recommended?

A

yes

28
Q

what is the 1st line Mx?

A

change lifestyle factors

29
Q

what is general diet advice?

-7

A
Eat regular
don’t skip meals, drink water
oats are good. 
No processed foods. Only 3 pieces of fruit/day. 
Less tea & coffee.
30
Q

1st line Mx for diarrhoea failed.

What drug can be given now?

A

loperamide

31
Q

1st line Mx for constipation failed.

What class of drug can be given now?

give an example of this class?

A

bulk forming laxative

fybogel

32
Q

IBS pt has refractory constipation.

what drug can you try now?

which messenger molecule is upregulated by this drug?

how does this help constipation?

A

linaclotide

↑cGMP

stimulates water, Cl- & HCO3- secretion into intestine lumen

33
Q

IBS pt has refractory abdo pain.

what is the 1st drug you should try?

A

amitriptyline

34
Q

all lifestyle factors and drug options have been exhausted.

symptoms still there.

who can GP refer to now?
- 3 specialties

A

Refer to gastroenterologist
Refer to dietician
Refer to psychiatrist

35
Q

moa of loperamide?

on which receptors in what plexus does it act?

which specific organ does it act in?

A

opioid-receptor agonist

μ-opioid receptors in the myenteric plexus

large intestine

36
Q

moa of loperamide?

how exactly does loperamide help diarrhoea?

A

↓tone of smooth muscle in LI –> ∴food stays longer in LI –> more water absorbed from food into blood.

37
Q

main effect of loperamide?

A

stops diarrhoea